Increased Sclerostin, but Not Dickkopf-1 Protein, Is Associated with Elevated Pulse Wave Velocity in Hemodialysis Subjects

Kidney & Blood Pressure Research
Eirini StavrinouAikaterini Papagianni

Abstract

Sclerostin and Dickkopf-1 (Dkk-1) proteins are inhibitors of the canonical Wnt/β-catenin bone pathway. Pilot data suggest that sclerostin may be involved in vascular changes in chronic kidney disease (CKD), but data on the effects of Dkk-1 are scarce. This is the first study investigating simultaneously the associations of sclerostin and Dkk-1 with arterial stiffness in hemodialysis patients. A total of 80 patients on chronic hemodialysis had carotid-femoral pulse wave velocity (PWV), central blood pressure (BP), and wave reflections evaluated with applanation tonometry (Sphygmocor) on a midweek non-dialysis day. Serum levels of sclerostin and Dkk-1 were measured with ELISA. A large set of demographic, comorbid, laboratory, and drug parameters were used in the analyses. Subjects with PWV >9.5 m/s (high arterial stiffness group, n = 40) were older, had higher BMI, higher prevalence of hypertension, diabetes, and coronary heart disease, and higher peripheral systolic BP, central systolic BP, C-reactive protein, and serum sclerostin (p = 0.02), but similar Dkk-1, compared to subjects with low PWV. When dichotomizing the population by sclerostin levels, those with high sclerostin had higher PWV than patients with low sclerostin lev...Continue Reading

References

Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Marcello TonelliAmit X Garg
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Jorge B Cannata-AndíaBernardino Díaz-López
Dec 21, 2007·Journal of the American Society of Nephrology : JASN·Sharon M Moe, Neal X Chen
Jan 8, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Stephanie S DeLoach, Raymond R Townsend
Jan 9, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M NavesJ B Cannata-Andía
Jan 16, 2009·Kidney International·Cecilia M Giachelli
Sep 11, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Francis VerbekeUNKNOWN CORD Study Investigators
Nov 15, 2011·Gene·David G MonroeJennifer J Westendorf
Mar 7, 2012·Atherosclerosis·Georg GoliaschWalter S Speidl
Apr 12, 2012·Cardiovascular Research·Carina Mill, Sarah Jane George
Nov 6, 2012·The Journal of Clinical Endocrinology and Metabolism·Thomas C RegisterBarry I Freedman
Jan 5, 2013·Diabetes Care·Sonia Morales-SantanaManuel Muñoz-Torres
Feb 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Solenne PelletierDenis Fouque
Jul 25, 2014·The Journal of Clinical Endocrinology and Metabolism·Mehmet KanbayMahmut Ilker Yilmaz
Jul 30, 2014·Néphrologie & thérapeutique·Lucie DesjardinsUNKNOWN European Uremic Toxin (EUTox) Work Group
Sep 25, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christiane DrechslerUNKNOWN NECOSAD Study Group
Nov 8, 2014·Nephron. Clinical Practice·Pierre DelanayeEtienne Cavalier
Apr 10, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marion MorenaJean-Paul Cristol
May 23, 2015·Kidney & Blood Pressure Research·Albina NowakBjörn Friedrich
Aug 20, 2015·Seminars in Dialysis·Rosa M A Moysés, Susan C Schiavi
Mar 25, 2017·Molecular Medicine Reports·Agostino GaudioCarmelo Erio Fiore
Oct 20, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre DelanayeEtienne Cavalier
Apr 26, 2018·Blood Purification·Gokce Kundakci GelirSim Kutlay

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