Increased secreted frizzled-related protein 4 and ficolin-3 levels in gestational diabetes mellitus women

Endocrine Journal
Xiao-Song YuanBin Yu

Abstract

By biochemical and epidemiological similarity with type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM) has some overlap between prediction markers and risk factors of T2DM. The present study aimed to establish that secreted frizzled-related protein 4 (SFRP4) and ficolin-3 levels, which have been linked to insulin resistance and the development of T2DM, are elevated in GDM women. A longitudinal prospective cohort study of 86 GDM and 273 normal glucose tolerant (NGT) pregnant women was performed. The clinical parameters, lipid profiles, and serum SFRP4 and ficolin-3 levels were tested during the early and late second-trimester and third-trimester of pregnancy. Both SFRP4 and ficolin-3 levels were significantly higher in GDM women as compared to the NGT participants at three test points (p < 0.01). Spearman's correlation analysis showed that serum SFRP4 levels were significantly positively correlated with ficolin-3 during the early and late second-trimester and third-trimester of pregnancy. The elevated SFRP4 and ficolin-3 concentrations at 16-18 weeks gestation significantly associated with GDM were conformed using binary logistic regression analysis after controlling for other variables [odds ratios (OR) with 95...Continue Reading

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Citations

Aug 3, 2019·Genetic Testing and Molecular Biomarkers·Qingquan Li, Yurong Lin
May 1, 2021·Journal of Clinical Medicine·Delia BogdanetPaula M O'Shea
Jun 5, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Zixin CaiJingjing Zhang
Jan 14, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Xiaochen Liu, Gaifeng Wang
Oct 13, 2021·Clinical Diabetes and Endocrinology·Daria Di FilippoAlec Welsh

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