Increased seizure susceptibility and cortical malformation in beta-catenin mutant mice

Biochemical and Biophysical Research Communications
Victor E CamposYuqing Li

Abstract

Beta-catenin has been implicated in epilepsy because of its altered post seizure expression and the role of Wnt2 signaling in autism. To determine beta-catenin's role in seizure susceptibility, we injected penetylenetetrazol intraperitoneally in beta-catenin cerebral cortex- and hippocampus-specific knockout mice. We then analyzed the latency, number, and duration of four phases of seizure behaviors: (I) non-seizure activity, (II) myoclonic jerks, (III) generalized clonic seizures, and (IV) tonic seizures. The latencies to both death and Phase IV were significantly reduced in mutant mice. Mutant mice also spent significantly more time in Phases III and IV and showed significantly less time in the non-convulsive state (Phase I). Nissl and gold chloride staining indicated that the knockout mice had underdeveloped cortices, lacked a corpus callosum, and were missing hippocampal structures. This suggests that dysfunction of beta-catenin-mediated signaling pathways in mice leads to cortical malformation and increased seizure susceptibility.

References

May 1, 1967·The Journal of Heredity·J L Fuller, F H Sjursen
Jul 8, 1999·Current Opinion in Neurobiology·R S Puranam, J O McNamara
Oct 9, 1999·Epilepsy Research·K M JacobsD A Prince
Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P J Morin
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M LiuD H Lowenstein
Mar 1, 2000·Biochemical and Biophysical Research Communications·H GuoY Li
Mar 21, 2000·Brain & Development·P Giovanardi RossiA Parmeggiani
Feb 7, 2001·The Journal of Biological Chemistry·S HosonoJ D Licht
Apr 25, 2000·Biochemical and Biophysical Research Communications·X L JinY Li
Jun 30, 2000·Biochemical and Biophysical Research Communications·H GuoY Li
Jul 27, 2000·Annals of the New York Academy of Sciences·J Behrens
Oct 12, 2000·Biochemical and Biophysical Research Communications·H GuoY Li
Nov 1, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N Barker, H Clevers
Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J W Swann, J J Hablitz
Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·P A Schwartzkroin, C A Walsh
Jul 13, 2001·American Journal of Medical Genetics·T H WassinkV C Sheffield
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·X XiaH Zheng
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Alexandre E MedinaSergio L Schmidt
Mar 14, 2002·Archives of Neurology·Brenda E PorterJeff A Golden
Jun 1, 2002·Science·Randall T MoonNorbert Perrimon
Jul 19, 2002·Neuron·Hideru TogashiMasatoshi Takeichi
Aug 27, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Steven N Roper, Anthony T Yachnis
Oct 22, 2002·Journal of Neuropathology and Experimental Neurology·Katrin FasenAiling A Lie
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Shinji HiranoChristoph Redies
Dec 11, 2002·The Journal of Cell Biology·Lisette HariLukas Sommer
Mar 19, 2003·Cancer Biology & Therapy·Jacquelyn Coyle-RinkShohreh Amini
Oct 7, 2003·Annual Review of Neuroscience·Jeffrey L Noebels
Oct 7, 2003·Nature Neuroscience·Xiang Yu, Robert C Malenka
Nov 19, 2003·Neuron·Shernaz X BamjiLouis F Reichardt
Dec 31, 2003·Epilepsy & Behavior : E&B·Orrin Devinsky, Rachel Laff

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Citations

Mar 2, 2006·Genes, Brain, and Behavior·D WahlstenH S Ozaki
Nov 26, 2013·Brain Research Bulletin·Hong-Tao WangZe-Lan Hu
Mar 13, 2014·The Journal of Clinical Investigation·Valter TucciPatrick M Nolan
Jul 6, 2012·Cellular and Molecular Life Sciences : CMLS·Mónica TapiaJuan José Garrido
Oct 28, 2005·Behavioral and Cognitive Neuroscience Reviews·Stephen C Gammie
Oct 12, 2018·Canadian Journal of Physiology and Pharmacology·Abdelaziz M HusseinOsama A Abulseoud
May 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chun-Ming ChenFu-Chin Liu
Mar 8, 2006·The European Journal of Neuroscience·Fiona FrancisJamel Chelly
Aug 9, 2019·Clinical Genetics·Kristin D KernohanSarah Dyack
Jan 8, 2019·Genesis : the Journal of Genetics and Development·Gregg DiNuoscio, Radhika P Atit
Jun 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jian ZhangJinmin Liu
May 17, 2019·Brain Sciences·Abdelaziz M HusseinOsama A Abulseoud
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia
Sep 4, 2021·European Journal of Pharmacology·Vipasha GautamLekha Saha
May 10, 2008·Neuron·Amy B VashlishanJoshua M Kaplan

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