Increased seizure susceptibility in adult rats with neuronal migration disorders

Brain Research
I M Germano, E F Sperber

Abstract

Recent data show that neuronal migration disorders (NMD) lower the seizure threshold in the immature brain. To assess if this is an age-related phenomenon, kainic acid (KA) was administered to induce status epilepticus in adult rats with NMD. Results of the present study demonstrate that adult rats with NMD had a shorter latency to seizures and longer duration of status epilepticus compared to age-related controls. Furthermore, in rats with NMD seizures were more severe and status epilepticus-induced mortality was worse than in age-matched controls. These data confirm that NMD lower the seizure threshold in the adult rat. The results of the present study combined with our previous studies in the immature rat, suggest that the facilitating effects of NMD on seizures are not age dependent.

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Citations

Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J W Swann, J J Hablitz
Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·P A Schwartzkroin, C A Walsh
Aug 30, 2002·Epilepsy Research·Matthew D SmythScott C Baraban
Oct 9, 1999·Epilepsy Research·K M JacobsD A Prince
Jul 14, 1999·Epilepsia·N Chevassus-au-LouisY Ben-Ari
Sep 22, 2011·Epilepsia·Naranzogt TschuluunPhilip A Schwartzkroin
Sep 8, 2012·Epilepsy Research and Treatment·Nathalie T SanonLionel Carmant
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Dec 29, 1998·Brain & Development·P D FisherS L Moshé
Apr 8, 2015·Journal of Neuroscience Methods·Heiko J Luhmann
Sep 3, 2014·CNS Neuroscience & Therapeutics·Françoise WatrinAlfonso Represa
Jul 13, 2004·Epilepsy Research·Robert S SloviterTimothy A Pedley
Nov 16, 2006·Annals of the New York Academy of Sciences·Libor Velísek
Aug 22, 2016·Seminars in Pediatric Neurology·Tarek ShakerLionel Carmant
Aug 27, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Steven N Roper, Anthony T Yachnis
Jun 16, 2007·Epilepsia·Cesare T Lombroso
Jul 2, 2003·Journal of Neuropathology and Experimental Neurology·Fabrizio GardoniMonica Di Luca
Apr 27, 2002·Journal of Neurophysiology·Lisa A Gabel, Joseph J LoTurco

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