Increased sensitivity of dopamine systems following reproductive experience in rats

Pharmacology, Biochemistry, and Behavior
Elizabeth M ByrnesR S Bridges

Abstract

Several studies have suggested that alterations in forebrain dopamine activity during the postpartum period may result in the onset of postpartum psychosis in women [J. Psychosom. Obstet. Gynecol. 19 (1998) 104; Prog. Neuro-Psychopharmacol. Biol. Psychiatry 17 (1993) 571; J. Clin. Psychiatry 51 (1990) 365.]. The present study investigated whether increased dopamine activity in these forebrain regions is a normal consequence of reproductive experience in rodents. Both intact and ovariectomized parous and nulliparous females were tested for their responses to the dopamine agonist apomorphine using two behavioral measures, prepulse inhibition (PPI) and oral stereotypy. In addition, dopamine and DOPAC levels were measured in tissue from the striatum and nucleus accumbens together with circulating plasma prolactin levels. The results of the behavioral studies demonstrate an increased response to apomorphine in parous females. Parous subjects also had increased levels of dopamine and DOPAC in striatal tissue and lower levels of circulating prolactin. Ovariectomy in nulliparous females resulted in a potentiated response to apomorphine with regard to the disruption of PPI, as well as a significant decrease in the plasma prolactin level...Continue Reading

References

Sep 1, 1991·Acta Psychiatrica Scandinavica·J L Klompenhouwer, A M van Hulst
Jan 29, 1987·The New England Journal of Medicine·V C MuseyJ R Preedy
May 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·R E KendellC Platz
Aug 1, 1987·Neuropharmacology·A KazandjianD D Varonos
Dec 1, 1986·Journal of Neurochemistry·R E Hruska
Sep 18, 1982·Lancet·J C Cookson
Dec 20, 1982·Life Sciences·T Di PaoloF Labrie
Jul 17, 1981·European Journal of Pharmacology·T Di PaoloF Labrie
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·F J WanN R Swerdlow
Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·G Díaz-VélizS Mora
Jan 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·C J MeakinS R Jones
Jan 1, 1993·Psychopathology·A Rhode, A Marneros
Jan 1, 1993·Schizophrenia Bulletin·D J Castle, R M Murray
Jul 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·R KumarS Checkley
Dec 15, 1995·Biological Psychiatry·D A SichelJ F Rosenbaum
Feb 1, 1997·Pharmacology, Biochemistry, and Behavior·S K YeghiayanR J Baldessarini
Jun 25, 1998·Journal of Psychosomatic Obstetrics and Gynaecology·N Deuchar, I Brockington
Jun 12, 1999·Psychopathology·B PfuhlmannG Stöber
Dec 11, 1999·Psychopharmacology·A Ahokas, M Aito
Mar 8, 2000·Acta Psychiatrica Scandinavica·A AhokasS Turiainen

❮ Previous
Next ❯

Citations

Jul 31, 2009·Behavior Genetics·Susanna Pietropaolo, Wim E Crusio
Jan 20, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eydie L Moses-KolkoWayne C Drevets
Oct 19, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elizabeth M ByrnesJohn J Byrnes
Feb 12, 2013·Annual Review of Clinical Psychology·Michael W O'Hara, Jennifer E McCabe
Feb 24, 2010·Frontiers in Neuroendocrinology·Valerie L HedgesRobert L Meisel
Oct 16, 2007·Physiology & Behavior·Alicia A Walf, Cheryl A Frye
Aug 9, 2011·Neuroscience Letters·John J ByrnesElizabeth M Byrnes
Mar 23, 2011·Journal of Reproductive Immunology·Maria Isabel Roth Carvalho-FreitasLuciano F Felicio
Jun 23, 2011·Neurochemistry International·Dean E Dluzen
Dec 17, 2014·Frontiers in Neuroendocrinology·Robert S Bridges
Sep 30, 2014·CNS Spectrums·Crystal Edler SchillerDavid R Rubinow
Oct 23, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C BeinfeldL F Felicio
Mar 12, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A P Serafim, L F Felicio
Dec 26, 2006·Expert Review of Neurotherapeutics·A M Mortimer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.