Increased sensitivity to alcohol induced changes in ERK Map kinase phosphorylation and memory disruption in adolescent as compared to adult C57BL/6J mice.

Behavioural Brain Research
Marina SpanosClyde Hodge

Abstract

Adolescence is a critical period of brain development that is accompanied by increased probability of risky behavior, such as alcohol use. Emerging research indicates that adolescents are differentially sensitive to the behavioral effects of acute ethanol as compared to adults but the neurobiological mechanisms of this effect remain to be fully elucidated. This study was designed to evaluate effects of acute ethanol on extracellular signal-regulated kinase phosphorylation (p-ERK1/2) in mesocorticolimbic brain regions. We also sought to determine if age-specific effects of ethanol on p-ERK1/2 are associated with ethanol-induced behavioral deficits on acquisition of the hippocampal-dependent novel object recognition (NOR) test. Adolescent and adult C57BL/6J mice were administered acute ethanol (0 0.5, 1, or 3g/kg, i.p.). Brains were removed 30-min post injection and processed for analysis of p-ERK1/2 immunoreactivity (IR). Additional groups of mice were administered ethanol (0 or 1g/kg) prior to the NOR test. Analysis of p-ERK1/2 IR showed that untreated adolescent mice had significantly higher levels of p-ERK1/2 IR in the nucleus accumbens shell, basolateral amygdala (BLA), central amygdala (CeA), and medial prefrontal cortex (m...Continue Reading

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Citations

Jan 10, 2013·Alcoholism, Clinical and Experimental Research·M Jerry WrightMichael A Taffe
Aug 8, 2015·Alcoholism, Clinical and Experimental Research·Abigail E AgogliaClyde W Hodge
Apr 27, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jenny MoletLaurence Lanfumey
Dec 21, 2016·Alcoholism, Clinical and Experimental Research·Christina L RubyH Scott Swartzwelder
Dec 15, 2020·Behavioural Brain Research·Lucas T LaudermilkRangan Maitra

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