PMID: 2121651Nov 15, 1990Paper

Increased sensitivity to two-stage skin carcinogenesis of mice heterozygous for the repeated epilation mutation (Er)

International Journal of Cancer. Journal International Du Cancer
A L Reddy, P J Fialkow

Abstract

Mice heterozygous for repeated epilation mutation (Er) have cutaneous abnormalities that result in repeated loss of hair. Skin papillomas and carcinomas occur spontaneously in such Er/+ mice. BALB/c mice are generally resistant to induced skin cancers. We investigated whether Er/+ heterozygous mice of BALB/c genetic background exhibit increased susceptibility to spontaneous and induced skin tumors. Although none of the Er/+ CXB(N5) mice spontaneously developed skin tumors, they exhibited increased sensitivity to the development of skin papillomas induced by an initiation-promotion regimen. Er/+ mice developed papillomas after 20 micrograms DMBA initiation in the absence of TPA promotion, but the same dose of DMBA was subtumorigenic in +/+ (sibling) mice. Although 15 weeks of TPA promotion resulted in similar tumor susceptibilities, tumor latencies and tumor frequencies in the 2 groups of initiated mice, the papillomas were qualitatively different. Er/+ mice developed more papillomas of the delayed promoter-independent type, which occur after termination of promotion. In contrast, +/+ mice developed more promoter-dependent papillomas, which regress after termination of promotion. Therefore Er/+ mice had a significantly higher nu...Continue Reading

References

Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
Mar 1, 1979·The Journal of Heredity·J L GuenetM T Tassin
Feb 1, 1982·The Journal of Cell Biology·K A HolbrookK S Brown

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Citations

Sep 20, 2011·Carcinogenesis·Qiutang LiQingxian Lu
May 4, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E Gallo-HendrikxA G Wildeman

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