Increased sequence conservation of domain repeats in prokaryotic proteins

Trends in Genetics : TIG
Dan ReshefOra Schueler-Furman

Abstract

Protein domain repeats within a protein sequence have been observed throughout all domains of life. Our analysis shows a significantly higher degree of sequence identity between repeated domains in prokaryotes compared to eukaryotes. We discuss this difference in the light of aggregation prevention, contribution to functional divergence and binding-related functions. We then address the possible underlying features that create and conserve domain repeats. Our findings provide a starting point for the identification of the fundamental principles that underlie this basic difference between eukaryotic and prokaryotic protein evolution.

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Citations

Mar 23, 2011·Bioinformatics and Biology Insights·Raphael D IsokpehiWellington K Ayensu
Apr 9, 2013·Current Opinion in Structural Biology·Erich Bornberg-Bauer, M Mar Albà
Sep 28, 2016·Molecular Biology and Evolution·Andreas Schüler, Erich Bornberg-Bauer
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