Increased serum β2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients

Lupus
M-L F HermansenS Jacobsen

Abstract

The objective of this study was to explore the relationship between serum levels of β2-microglobulin (β2MG), which some studies suggest reflect disease activity in systemic lupus erythematosus (SLE), and various clinical and immunological markers of disease activity in SLE. Twenty-six SLE patients and 10 healthy controls were included. Disease activity was assessed by: SLEDAI, 24 hr-proteinuria, circulating levels of complement C3, anti-double-stranded DNA (anti-dsDNA), β2MG and various pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10, IL-18) measured with a multiplex assay, IFN-α assessed with a reporter gene assay, and a combined expression score of 12 IFN-α inducible genes in peripheral blood mononuclear cells. Median serum levels of β2MG were significantly higher in SLE patients vs controls (2.8 mg/L, range: 1.1-21.6 and 1.2 mg/L, range: 0.9-1.7, respectively, p < 0.001). β2MG was correlated with SLEDAI score (R = 0.68, p < 0.001), 24 hr-proteinuria (R = 0.64, p < 0.001), and complement C3 (R = -0.52, p = 0.007). The cytokines were significantly correlated with β2MG: IL-6 (R = 0.45, p = 0.02), IL-8 (R = 0.75, p < 0.001), IL-10 (R = 0.67, p < 0.001) and IL-18 (R = 0.71, p < 0.001) as were serum IFN-α (R = ...Continue Reading

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Citations

Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·Anna Nuttall, David A Isenberg
Aug 4, 2012·Cytokine·Julia BarbadoJesus F Bermejo-Martin
Mar 1, 2012·Revista clínica española·G Ruiz-IrastorzaUNKNOWN Sociedad Española de Nefrología
Jul 24, 2014·São Paulo Medical Journal = Revista Paulista De Medicina·Thelma Larocca SkareMarcela Aimone Santos
Mar 30, 2017·SAGE Open Medicine·John Q YoungPatricia S O'Sullivan
Apr 29, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asaf MadiIrun R Cohen
Jul 1, 2017·Frontiers in Medicine·Christos P ArgyropoulosAntonios H Tzamaloukas
Mar 14, 2021·Multiple Sclerosis and Related Disorders·Lin-Jie ZhangLi Yang

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