Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes

Journal of Diabetes Research
Yanhua YinHaiyan Sun

Abstract

The objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were determined using ELISA in 22 subjects with NGT (normal glucose tolerance), 74 subjects with IGR (impaired glucose regulation), and 33 subjects with T2DM (type 2 diabetes mellitus). Subjects with IFG, IGT, CGI, and T2DM had higher levels of serum ANGPTL8 than subjects with NGT. Serum ANGPTL8 was positively correlated with FPG, fasting C-peptide, and postprandial C-peptide and negatively correlated with BETA/IR when adjusted for age and BMI. Multivariate analysis suggested FPG and fasting C-peptide as independent factors associated with serum ANGPTL8 levels. Serum ANGPTL8 concentrations were significantly increased in IGR and T2DM. Serum ANGPTL8 might play a role in the pathological mechanism of glucose intolerance.

References

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Citations

Nov 28, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Chang GuoGuoyue Yuan
May 1, 2021·International Journal of Molecular Sciences·Hyunmi KimKyoung-Jin Oh
May 24, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xin SuBin Wang
Sep 29, 2021·Open Biology·Chang GuoGuoyue Yuan

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Methods Mentioned

BETA
ELISA

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