Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
P Ø JensenN Høiby

Abstract

Chronic Pseudomonas aeruginosa lung infection is the major reason for premature death in patients with cystic fibrosis (CF). Infected patients experience a progressive deterioration of the lung tissue caused by a persistent accumulation of PMNs. We investigated if the pulmonary accumulation of PMNs is reflected as a migration of PMNs through the blood in chronically infected CF patients. Blood and sputum samples from 37 stable, chronically (CF+P) and 6 non-infected (CF-P) CF patients without exacerbations were compared using FACS, leukocyte counting, and ELISA. Within the CF+P patients, the blood parameters were compared to the lung function (FEV1 and FVC) and to the sputum. Similar measurements were performed on 15 chronically infected CF patients before and after elective antibiotic treatment. In the CF+P patients the concentration of G-CSF in the sera and PMNs in the blood was increased and correlated to poor lung function. However, only the concentration of G-CSF in the sera was correlated to the concentration of TNF-alpha in the sputum. After the antibiotic treatment, the lung function was improved and the concentration of PMNs in the blood and G-CSF in the sera was reduced. G-CSF in the sera may contribute to the pulmonar...Continue Reading

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Citations

Aug 27, 2013·PloS One·George M SolomonSteven M Rowe
Jul 27, 2007·Proceedings of the American Thoracic Society·Scott D SagelMichael W Konstan
Nov 21, 2007·Molecular Medicine·Minou Adib-ConquyJean-Marc Cavaillon
Mar 13, 2014·Clinical and Experimental Immunology·M KolpenP Ø Jensen
Nov 1, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Emer P ReevesNoel G McElvaney
Nov 27, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·C R HansenN Høiby
May 23, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Pasqualina MontemurroMassimo Conese
Dec 3, 2014·International Journal of Medical Microbiology : IJMM·Mette KolpenPeter Østrup Jensen
Jun 29, 2010·FEMS Immunology and Medical Microbiology·Peter Østrup JensenClaus Moser
Apr 14, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Claus MoserPeter Østrup Jensen
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Mark D DeBoer
Feb 26, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Claus MoserNiels Høiby
Sep 12, 2019·Scientific Reports·Stefano CastellaniMassimo Conese
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Mar 12, 2021·Frontiers in Immunology·Claus MoserTim Tolker-Nielsen

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