PMID: 9545110Apr 17, 1998Paper

Increased serum concentration of interleukin-5 in patients with Graves' disease and Hashimoto's thyroiditis

Thyroid : Official Journal of the American Thyroid Association
Y HidakaN Amino

Abstract

We investigated serum levels of interleukin-5 (IL-5) in order to examine the role of T-helper 2 (Th2)-type immune response in the pathogenesis of autoimmune thyroid diseases. Serum levels of IL-5 were determined by a highly sensitive sandwich enzyme-linked immunosorbent assay in 42 patients with Graves' disease, 32 patients with Hashimoto's thyroiditis, 12 patients with silent thyroiditis, and 21 normal controls. Compared with serum levels in normal subjects (5.8 +/- 4.2 pg/mL), IL-5 was increased in patients with Graves' disease (16.4 +/- 16.7 pg/mL, p < .01), and in patients with Hashimoto's thyroiditis (10.0 +/- 7.6 pg/mL, p < .05), but not in patients with silent thyroiditis. There was no correlation between serum free thyroxine (FT4) and IL-5 levels. These data suggest an important role of the Th2-type immune response in the pathogenesis of Graves' disease and Hashimoto's thyroiditis.

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Citations

May 5, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·T LalaniA R Ahmed
Oct 9, 2002·Journal of Internal Medicine·G MazziottiC Carella
Apr 18, 2003·Thyroid : Official Journal of the American Thyroid Association·Sandra M McLachlan
Apr 18, 2003·Thyroid : Official Journal of the American Thyroid Association·Yoh HidakaNobuyuki Amino
Jun 14, 2003·Thyroid : Official Journal of the American Thyroid Association·Yumi NakamotoYoshinori Iwatani
Oct 16, 2003·Thyroid : Official Journal of the American Thyroid Association·Nobuyuki AminoYukiko Nakata
Mar 25, 1999·Thyroid : Official Journal of the American Thyroid Association·Y HidakaN Amino
May 13, 1999·Thyroid : Official Journal of the American Thyroid Association·M OkumuraN Amino
Oct 21, 2000·Thyroid : Official Journal of the American Thyroid Association·S MiyauchiM Onji
Jan 5, 2020·International Journal of Immunogenetics·Souhir MestiriHela Marmouch
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beiling ChenTerry J Smith
Jul 22, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Chen-Shen HuangRen-Bin Tang
Dec 13, 2003·Autoimmunity·R A Ajjan, A P Weetman

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