Abstract
This study investigated serum levels of the soluble form of CD30 (sCD30), which is mainly secreted from T helper 2(Th2) cells, in autoimmune thyroid diseases. The possible relationship of sCD30 to autoantibody production was also evaluated. Serum levels of sCD30 were determined by an enzyme-linked immunosorbent assay in 71 patients with Graves' disease, 37 patients with Hashimoto's thyroiditis, and 21 normal donors. Compared with normal subjects (7.1 +/- 4.5 U/mL), sCD30 was increased in patients with Graves' disease (29.2 +/- 25.2 U/mL, P < 0.0001) and in patients with Hashimoto's thyroiditis (29.9 +/- 26.9 U/mL, P < 0.0001). In Graves' disease, sCD30 levels were higher in thyrotoxic patients (41.7 +/- 31.2 U/mL, P < 0.001) than in remission patients (15.8 +/- 11.0 U/mL), and a significant correlation was observed between sCD30 levels and serum activities of TSH receptor antibody (r = 0.444, P < 0.0001). In Hashimoto's thyroiditis, sCD30 levels were higher in patients with transient destructive thyrotoxicosis caused by the aggravation of the disease (48.8 +/- 34.4 U/mL, P < 0.05) than in euthyroid patients (24.2 +/- 19.4 U/mL). These data suggest that serum sCD30 is a valuable marker of disease activity and support an importan...Continue Reading
References
Feb 7, 1992·Cell·H DürkopH Stein
Jan 1, 1989·European Journal of Immunology·O Josimovic-AlasevicT Diamantstein
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·W A MacKenzieT F Davies
Aug 1, 1987·The Journal of Clinical Endocrinology and Metabolism·H TamakiK Miyai
Jan 1, 1985·Endocrine Reviews·K D Burman, J R Baker
Oct 1, 1984·The Journal of Clinical Endocrinology and Metabolism·U BognerJ R Wall
Sep 2, 1982·Nature·U SchwabV Diehl
Dec 1, 1995·The Journal of Experimental Medicine·G Del PreteS Romagnani
Jul 1, 1995·The Journal of Clinical Investigation·R J MullinsM Feldmann
Dec 1, 1993·The Journal of Clinical Endocrinology and Metabolism·L ChiovatoA Pinchera
Jun 1, 1994·AIDS·G PizzoloH Stein
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G NadaliA Vassanelli
Sep 1, 1993·Clinical and Experimental Immunology·Y IwataniN Amino
Jul 2, 1993·Cell·C A SmithN A Jenkins
Dec 1, 1995·Clinical and Experimental Immunology·R GerliA Bertotto
Apr 1, 1996·Thyroid : Official Journal of the American Thyroid Association·M HeuerW A Scherbaum
Mar 1, 1996·Immunology·A BarnardK H Mills
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Aug 1, 1996·Thyroid : Official Journal of the American Thyroid Association·Y HidakaN Amino
Citations
Sep 6, 2000·Clinical and Experimental Immunology·I M WakelkampW M Wiersinga
Mar 6, 2002·Clinical and Experimental Immunology·M Ludgate, G Baker
Sep 4, 2012·Human Immunology·Sonia Y VelásquezCristiam M Alvarez
Jan 28, 2014·Current Therapeutic Research, Clinical and Experimental·Ahmet GuneyKemal Deniz
Sep 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anas Younes, Marshall E Kadin
Sep 14, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juan Pedro KusanovicJimmy Espinoza
Feb 20, 2010·Autoimmunity·N PerioloA C Cherñavsky
Dec 6, 2019·Eye·Ahmed M Abu El-AsrarSofie Struyf