Increased serum concentrations of human hepatocyte growth factor in proliferative diabetic retinopathy

The Journal of Clinical Endocrinology and Metabolism
M NishimuraM Yoshimura

Abstract

Human hepatocyte growth factor (hHGF) is a powerful inducer of angiogenesis. We investigated the relationship between serum hHGF concentrations and proliferative diabetic retinopathy, the major characteristic of which is retinal neovascularization. Serum hHGF concentrations were measured in diabetic (n = 135) and nondiabetic subjects (n = 80). The mean serum hHGF concentration in diabetic subjects without retinopathy was lower than that in nondiabetic subjects [0.041 +/- 0.003 ng/mL (n = 62) vs. 0.080 +/- 0.010 ng/mL (n = 80); P < 0.05], but was not different from that in diabetic subjects with background retinopathy (0.058 +/- 0.007 ng/mL; n = 26) or preproliferative retinopathy (0.048 +/- 0.010 ng/mL; n = 10). The mean serum hHGF concentration was increased in subjects with proliferative retinopathy who had not undergone photocoagulation (0.213 +/- 0.025 ng/mL; n = 24), but not in those who had undergone photocoagulation (0.040 +/- 0.008 ng/mL; n = 13). Circulating hHGF may be involved in the mechanism of neovascularization in the proliferative diabetic retinopathy, and measurement of serum hHGF may be helpful in predicting the presence of proliferative retinopathy in diabetic subjects.

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Citations

Jun 30, 2000·The British Journal of Ophthalmology·A CantónR Simó
Nov 30, 2012·Metabolism: Clinical and Experimental·Barbora de CourtenRobert V Considine
Apr 23, 2003·Journal of the American College of Cardiology·Jalees RehmanKeith L March
Mar 8, 2000·American Journal of Ophthalmology·L MasmiquelR Simó
Mar 23, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A SaikiK Shirai
Jun 8, 2006·American Journal of Physiology. Endocrinology and Metabolism·Lauren N BellRobert V Considine
Mar 9, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·X H XuQ H Liu
May 18, 2006·Acta Ophthalmologica Scandinavica·Anders Kvanta
Feb 18, 1999·The Journal of Clinical Endocrinology and Metabolism·M NishimuraM Yoshimura
Apr 27, 2013·Acta Ophthalmologica·Giacomo CavallaroFabio Mosca
Jul 23, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Bruna S LimaSinval P Brandão-Filho
Mar 16, 2004·Pediatric Diabetes·C Giusti
May 17, 2017·Journal of Neuroscience Research·Hiromi MuraseHideaki Hara

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