Increased serum cortisol on oral food challenge in infants with food protein-induced enterocolitis syndrome

Pediatrics International : Official Journal of the Japan Pediatric Society
Masaki ShimomuraMitsuaki Kimura

Abstract

An increase in absolute neutrophil count (ANC) is seen after oral food challenge test (OFC) in patients with food protein-induced enterocolitis syndrome (FPIES). Although it has been suggested that interleukin (IL)-8 is involved in this phenomenon, a possible role for cortisol has not yet been studied. Six positive OFC in five patients with FPIES due to cows' milk (CM) proteins, and two negative OFC in two patients with suspected FPIES were analyzed. Absolute neutrophil count, serum IL-8, and serum cortisol were measured before OFC, 6 and 24 h after the ingestion of CM formula. For the positive OFC, ANC measured 6 h after the ingestion of CM formula was significantly higher than that measured before the OFC (median, 8,761 versus 2,297/μL; P < 0.05). Significant increases in serum cortisol and IL-8 were observed 6 h after OFC (cortisol, median 1,119 pg/mL before versus 2,141 pg/mL after, P < 0.05; IL-8, median 15.5 pg/mL before versus 165.3 pg/mL after, P < 0.05). The change ratio (i.e. ratio of that after OFC to that before OFC) of ANC was significantly correlated not only with that of serum IL-8 (r = 0.90, P < 0.01) but also with that of serum cortisol (r = 0.76, P < 0.05). Moreover, the serum cortisol change ratio was signifi...Continue Reading

References

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Jan 30, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuaki KimuraShiro Seto
Aug 23, 2016·The Journal of Allergy and Clinical Immunology·Jean Christoph CaubetAnna Nowak-Węgrzyn
Sep 15, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Mitsuaki KimuraShiro Seto
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Jan 7, 2017·Allergology International : Official Journal of the Japanese Society of Allergology·Mitsuaki KimuraShiro Seto
Apr 23, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuaki KimuraTakaaki Meguro
Jan 1, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Atsuo UrisuUNKNOWN Japanese Society of Allergology

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Citations

Nov 8, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuaki KimuraTakaaki Meguro
Jan 26, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Stephanie A LeonardAnna Nowak-Węgrzyn
Feb 7, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M Cecilia Berin

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