Increased Serum G Protein-coupled Estrogen Receptor 1 Levels and Its Diagnostic Value in Drug Naïve Patients with Major Depressive Disorder

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Ebru FindikliHatice Altun

Abstract

The facts that depression is more prevalent in females than in males and females are exposed to depression more commonly during certain hormonal fluctuating periods indicate the role of sex hormones in physiopathology. Estrogen acts over estrogen receptors alpha and beta and recently identified G protein-coupled estrogen receptor 1 (GPER1). The present study aimed, for the first time, to evaluate serum GPER1 levels in drug-naïve major depressive disorder (MDD) patients. The study included 56 newly diagnosed drug-naïve MDD patients aged between 18 and 50 years and 42 age- and gender-matched healthy volunteers. Medical history was obtained and physical examinations, laboratory tests, and the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A) were performed. The serum GPER1 levels were measured. The HAM-D score was significantly higher in the MDD patients than in the controls. The GPER1 level was significantly higher in the MDD patients than in the controls. A positive correlation was found with GPER1 levels and depression scores. The receiver operating characteristic analysis revealed sensitivity, specificity, positive predictive value, and negative predictive value as 82.1%, 90.5%, 92.0%, and 79.2%, ...Continue Reading

References

Jun 28, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M CyrT Di Paolo
Jul 11, 2001·Trends in Endocrinology and Metabolism : TEM·T van AmelsvoortD Murphy
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·W KrezelP F Chapman
Jan 25, 2002·Annals of the New York Academy of Sciences·K Yaffe
Apr 13, 2004·International Clinical Psychopharmacology·M Erkan OzcanOmer Akyol
Jul 28, 2004·International Review of Psychiatry·J L Payne
Feb 12, 2005·Science·Chetana M RevankarEric R Prossnitz
Sep 27, 2005·Journal of Women's Health·Michael E ThaseSusan G Kornstein
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
Sep 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Walter WittmannChristoph Schwarzer
Feb 4, 2009·Psychosomatic Medicine·M Bryant HowrenJerry Suls
Mar 12, 2009·Physiology & Behavior·Matia B Solomon, James P Herman
May 12, 2009·Nature Chemical Biology·Megan K DennisEric R Prossnitz
May 16, 2009·Prostaglandins & Other Lipid Mediators·Eric R Prossnitz, Matthias Barton
Dec 26, 2009·Steroids·Gernot LangerChristiane Otto
Aug 17, 2011·Nature Reviews. Endocrinology·Eric R Prossnitz, Matthias Barton
Sep 1, 2011·Climacteric : the Journal of the International Menopause Society·J W Studd
Nov 25, 2011·Cellular and Molecular Neurobiology·J P ter HorstM S Oitzl
Jan 10, 2012·Biological Psychiatry·Saloua BenmansourAlan Frazer
Mar 1, 2012·The Psychiatric Clinics of North America·Ronald C Kessler
Mar 8, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John Studd, Rossella E Nappi
Mar 8, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Guichun HanRichard E White
Feb 18, 2014·Molecular and Cellular Endocrinology·Eric R Prossnitz, Matthias Barton
Jul 15, 2015·Social Psychiatry and Psychiatric Epidemiology·K KeyesK Koenen
Sep 12, 2015·Journal of Menopausal Medicine·Mi-Jin KimHae-Hyeog Lee

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Citations

Jan 29, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Saime SagirogluMehmet Akif Kılıc
Nov 17, 2020·Frontiers in Endocrinology·Janine L Dovey, Nandini Vasudevan
Jan 6, 2021·International Journal of Molecular Sciences·Wu Jeong HwangJun Soo Kwon

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

Statistical Package for the Social Sciences
SPSS

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