PMID: 9426380Jan 14, 1998Paper

Increased serum GHBP levels in obese pubertal children and adolescents: relationship to body composition, leptin and indicators of metabolic disturbances

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
J KratzschM Wabitsch

Abstract

The serum concentration of the high-affinity growth hormone-binding protein (GHBP) is increased in obesity but the mechanisms are poorly understood. This study assessed the physiological mechanisms involved in the regulation of GHBP in adiposity. We tested a number of obesity specific parameters for their association with GHBP. In this study, 199 normal or overweight children and adolescents (101 boys, 98 girls, aged (mean +/- s.d.): 13.7 +/- 2.3 y) underwent an anthropometric evaluation (circumference measurements and bioimpedance analysis) combined with blood withdrawal for the measurement of insulin-like growth factor-I (IGF-I), insulin, leptin and GHBP (by specific RIA), uric acid, triglycerides and cholesterol. By linear regression analysis GHBP correlated significantly (P < 0.001) with percent body fat mass (r = 0.71), waist (r = 0.73) and hip (r = 0.69) circumference, weight (r = 0.61) waist hip ratio (WHR) (r = 0.54), as well as with the serum concentrations of leptin (r = 0.64), uric acid (r = 0.54), insulin (r = 0.45), LDL-cholesterol (r = 0.43), cholesterol (r =0.33), LDL/HDL ratio (r = 0.47), triglycerides (r = 0.30) and with height standard deviations scores (SDS) (r = 0.23). Age, gender and pubertal stage had no i...Continue Reading

Citations

Sep 21, 2007·Calcified Tissue International·J Antonio Bermudez de la VegaRamón Pérez-Cano
Jan 5, 2000·Molecular and Cellular Endocrinology·M J HolnessM C Sugden
Apr 9, 2008·The British Journal of Nutrition·Jana Parizkova
Jul 27, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C DenzerM Wabitsch
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·A GartenW Kiess
Mar 12, 2010·The Veterinary Clinics of North America. Small Animal Practice·Dong Yong Kil, Kelly S Swanson
Dec 20, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Sanne Fisker
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Evelyn ArtzMichael Freemark
Jul 1, 2005·Metabolism: Clinical and Experimental·Heinz ZotterMartin Borkenstein
Apr 20, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·C M FlorkowskiR A Donald
Nov 24, 1999·Frontiers in Neuroendocrinology·F F Casanueva, C Dieguez
Mar 3, 2005·Medicine and Science in Sports and Exercise·Martyn R RubinWesley C Hymer
Jul 9, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·María Gabriela BalleriniHéctor Guillermo Jasper

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