PMID: 7523270Nov 1, 1994Paper

Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis C

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M OshitaT Kamada

Abstract

Hepatitis viruses and alcohol are major causes of liver disease. This study was aimed at investigating the effect of alcohol intake on the replication of hepatitis C virus and the efficacy of interferon therapy. Fifty-three patients who were histologically proved to have chronic hepatitis C were tested. Of these, 16 were diagnosed as habitual drinkers whose cumulative total consumption of alcohol was more than 100 kg or who had consumed at least 60 gm of ethanol daily for at least 5 yr. The quantities of hepatitis C virus RNA in serum were measured with a competitive assay that combined reverse transcription and polymerase chain reaction. The subjects received a 26-wk course of interferon-alpha therapy. There were no significant differences in age and ALT levels between habitual drinkers and nonhabitual drinkers. The titer of viral RNA (logarithmic transformed copy numbers per milliliter of serum) of habitual drinkers (8.5 +/- 0.5) was higher than that of nonhabitual drinkers (7.7 +/- 0.8) (p < 0.01). Neopterin levels in serum, a marker for the activation of cell-mediated immunity, were lower for habitual drinkers (5.7 +/- 1.5 pmol/ml) than for nonhabitual drinkers (8.1 +/- 5.0 pmol/ml) (p < 0.01). Eleven of the nonhabitual dri...Continue Reading

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K YoshiokaT Morishima
Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H HagiwaraT Kamada
May 1, 1992·Journal of Gastroenterology and Hepatology·S ShiomiS Harihara
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A ParésJ Rodés
Nov 1, 1989·Seminars in Liver Disease·G L Davis
Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H P DienesS C Meuer
Sep 19, 1986·JAMA : the Journal of the American Medical Association·R R MacGregor
Jun 10, 1982·The New England Journal of Medicine·C BréchotP Berthelot
Aug 7, 1981·JAMA : the Journal of the American Medical Association·M J EckardtK R Warren
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H HagiwaraT Kamada

❮ Previous
Next ❯

Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F PessioneB Rueff
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T E WileyT J Layden
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T V InglesbyD L Thomas
Oct 29, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·F A CasavillaJ J Fung
Feb 1, 2000·The American Journal of Medicine·E R Schiff
Mar 23, 2000·Journal of Hepatology·N Boyer, P Marcellin
Dec 1, 1996·Journal of Hepatology·S L CromieF J Dudley
Apr 20, 1999·Journal of Hepatology·H ZylberbergS Pol
Jan 6, 2000·Journal of Hepatology·F Degos
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S SachithanandanJ F Fielding
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·M Mazen Jamal, Timothy R Morgan
Oct 12, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Adnan SaidMichael R Lucey
Jan 12, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Romero-GómezM Castro
Jul 25, 1998·Alimentary Pharmacology & Therapeutics·C L MabeeW M Lee
Apr 24, 2009·Seminars in Liver Disease·Larry SiuJack R Wands
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Keigo MachidaMichael M-C Lai
Jan 25, 2003·Journal of Clinical Gastroenterology·Miguel A SerraJosé M Rodrigo
Jun 20, 2001·Gut·J C BoothUNKNOWN Thr Royal College of Physicians of London and the British Society of Gastroenterology
Feb 19, 2011·Gastroenterology Research and Practice·Keigo Machida
Jan 7, 2011·Journal of Transplantation·Marco Carbone, James Neuberger
Nov 14, 2006·Harm Reduction Journal·Curtis L Cooper, Edward J Mills
Aug 7, 2008·Journal of Addictive Diseases·Curtis L Cooper
Jun 14, 2002·The Lancet Infectious Diseases·Sandro Vento, Francesca Cainelli
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick MarcellinNathalie Boyer
Oct 1, 1996·Journal of Gastroenterology·H SaitoH Ishii
May 2, 1998·Medizinische Klinik·W FischbachW E Fleig
Aug 19, 2007·Journal of Clinical Gastroenterology·Ashwani K Singal, Bhupinder S Anand
Mar 5, 2013·Biochemical and Biophysical Research Communications·Nogol RahbinErwin Daniel Brenndörfer
Oct 30, 2012·Clinics in Liver Disease·Priya Grewal, Vijay Anand Viswanathen
Jul 8, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S GittoM Bernardi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved