PMID: 15331535Aug 28, 2004Paper

Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase

Diabetes
Y TerauchiTakashi Kadowaki

Abstract

Mice lacking the p85alpha regulatory subunit of phosphoinositide (PI) 3-kinase (Pik3r1(-/-)) showed increased glucose uptake in white adipose tissue (WAT) and skeletal muscle due to increased phosphatidylinositol (3,4,5)-triphosphate [PtdIns(3,4,5)P3] production and on a normal diet had a body weight and fat mass similar to wild-type mice. After 3 months on a high-fat diet, Pik3r1(-/-) mice still had increased insulin sensitivity and better glucose tolerance than wild-type mice, but showed markedly greater increases in body weight and WAT mass than wild-type mice. On the normal diet, serum leptin levels of Pik3r1(-/-) mice were significantly higher than in wild-type mice as a result of increased leptin secretion from adipocytes, presumably due to the increased PtdIns(3,4,5)P3 production in adipocytes. Leptin (5 microg/g body wt per day) caused a reduction in food intake and decrease in body weight by the wild-type mice as well as Pik3r1(-/-) mice, suggesting Pik3r1(-/-) mice having leptin sensitivity similar to wild-type mice. The slightly increased serum leptin compensated for the increased glucose uptake by adipocytes in Pik3r1(-/-) mice, thereby preventing adiposity on the normal diet. On the high-fat diet, leptin (5 microg/...Continue Reading

References

Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·S IkemotoO Ezaki
Jan 1, 1994·Analytical Biochemistry·R Lagunas, J C Díez-Masa
Apr 16, 1996·Biochemical and Biophysical Research Communications·K MaedaK Matsubara
May 3, 1996·The Journal of Biological Chemistry·E HuB M Spiegelman
Apr 1, 1996·Current Opinion in Cell Biology·C L Carpenter, L C Cantley
Nov 1, 1996·Cell·B M Spiegelman, J S Flier
Oct 1, 1996·Endocrine Journal·T KadowakiY Yazaki
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·J FruebisH F Lodish
Aug 2, 2001·Nature Medicine·A H BergP E Scherer
Oct 26, 2001·Nature·M KlaassenT Piersma

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Citations

Apr 29, 2005·Diabetes/metabolism Research and Reviews
Jun 8, 2018·Acta Pharmacologica Sinica·Niki KatsikiMaciej Banach
Dec 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Galina ApostolovaAlex Odermatt
Jan 10, 2019·International Journal of Molecular Sciences·Qi-Yuan HuangLi-Xia Xiong
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi
Jan 30, 2009·American Journal of Physiology. Endocrinology and Metabolism·Kazutaka AokiYasuo Terauchi
Jan 1, 2021·International Journal of Molecular Sciences·Thomas Ho-Yin Lee, Suk-Yu Yau

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