Increased serum level of interleukin-6 in patients with psoriatic arthritis and thrombocytosis

The Journal of Dermatology
S YasumotoY Hori

Abstract

The role of elevations of serum cytokines in psoriasis is a provocative issue. We report two patients with psoriasis who had episodes of fever, arthritis, and general fatigue. Their symptoms seemed to be associated with increases in serum levels of interleukin (IL)-6, which paralleled the severity of clinical symptoms as well as elevated serum titers of C-reactive protein (CRP) and platelet counts. Since IL-6 is a multipotential cytokine with B-cell activating, T-cell activating, and thrombocytopoietic functions, the symptoms and abnormal laboratory findings in these patients may have been related to their increased serum levels of IL-6. Monitoring the serum level of this cytokine may thus be useful in evaluating the clinical status of patients with psoriatic arthritis.

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Citations

Jan 26, 2016·Seminars in Dialysis·Maurizio Bossola, Luigi Tazza
Apr 30, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Laxmisha ChandrashekarDebdatta Basu
May 1, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Aldona T PietrzakJacek M Roliński
Sep 16, 2011·Seminars in Dialysis·Maurizio BossolaLuigi Tazza
Apr 6, 2002·Clinics in Laboratory Medicine·Alvaro Moreno, David Menke
Aug 20, 2014·Journal of Pain and Symptom Management·Maurizio BossolaLuigi Tazza
Aug 28, 2015·Journal of Pharmacology & Pharmacotherapeutics·Cherukuri TejaswiKaliaperumal Karthikeyan
Sep 16, 2006·Current Rheumatology Reports·Lotus MallbrisMona Ståhle
Sep 25, 2010·Renal Failure·Maurizio BossolaLuigi Tazza

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