PMID: 6172988Nov 1, 1981Paper

Increased serum levels of an interferon-like activity during the acute period of experimental infection with different strains of Trypanosoma cruzi

The American Journal of Tropical Medicine and Hygiene
G Sonnenfeld, F Kierszenbaum

Abstract

A marked development of an interferon-like antiviral activity was observed in the serum of mice infected with Tulahuén strain Trypanosoma cruzi as early as 24 hours after infection with 500 parasites. Such activity remained elevated until 48 hours postinfection and was reduced to undetectable levels--characteristic of normal, uninfected animals--by 72 hours. Infection with 10(4) Tulahuén strain T. cruzi resulted in production of somewhat lesser levels of interferon activity detectable 12 and 24 hours postinfection but not after 48 hours. Infection with 500 parasites of the Y strain was also followed by an increased interferon-like activity but this was not detectable until day 2 postinfection. During the chronic phase of the disease, interferon-like activity levels were indistinguishable from those of uninfected animals. The possibility that interferon activity may have a regulatory effect on the course of the infection is discussed.

Citations

Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vlaudia M A CostaIses A Abrahamsohn
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ritsuko KogaKiyoshi Takeda
Nov 18, 2004·Immunological Reviews·Christian BogdanUlrike Schleicher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.