PMID: 2504798Sep 1, 1989Paper

Increased serum levels of fibrinogen degradation products due to treatment with recombinant tissue-type plasminogen activator for acute myocardial infarction are related to bleeding complications, but not to coronary patency. European Co-operative Study Groups for rt-PA

Journal of the American College of Cardiology
A E ArnoldM Verstraete

Abstract

The association of increasing serum levels of fibrinogen degradation products after recombinant tissue-type plasminogen activator (rt-PA) therapy with bleeding and early coronary patency was assessed in 242 patients with acute myocardial infarction. After administration of 5,000 IU heparin, a median of 40 mg (range 35 to 60) of double chain rt-PA was given intravenously in 90 min. Bleeding occurred in 62 patients; in 73% of patients it was observed within the 1st 24 h and 84% of events consisted of hematoma or prolonged bleeding, or both, at puncture sites. Bleeding events occurred 2.12 times as often in patients with serum levels of fibrinogen degradation products greater than 85 mg/liter as in patients with serum levels less than 22 mg/liter (95% confidence interval 1.01 to 4.43). The infarct-related coronary vessel was patent in 65% of patients at 90 min after the start of rt-PA infusion. In patients with high serum levels of fibrin(ogen) degradation products, coronary patency at 90 min after the start of rt-PA infusion was not better (13% less, 95% confidence interval - 33%, 13%) than in patients with low serum levels. This uncoupling of thrombolytic effect in terms of coronary patency and systemic fibrinogenolysis confirms...Continue Reading

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Citations

Jul 1, 1999·Clinics in Chest Medicine·G S Francis
Feb 12, 2013·Expert Opinion on Biological Therapy·Bartlomiej Piechowski-Jozwiak, Julien Bogousslavsky
Sep 10, 2015·Ultrasound in Medicine & Biology·Florian C RoesslerJürgen Eggers
Apr 1, 1992·Chest·G Agnelli, P Parise
May 22, 2009·Expert Opinion on Biological Therapy·Maurizio PaciaroniJulien Bogousslavsky
Oct 30, 2004·Stroke; a Journal of Cerebral Circulation·Askiel Bruno
Dec 4, 1992·Annals of the New York Academy of Sciences·R Fears
Oct 27, 1995·The Journal of Biological Chemistry·P BringmannP Donner

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