Increased serum levels of soluble IL-2 receptor, CD30 and CD8 molecules, and gamma-interferon in angioimmunoblastic lymphadenopathy: possible pathogenetic role of immunoactivation mechanisms

British Journal of Haematology
G PizzoloT Diamantstein

Abstract

Abnormal immunoreaction associated with increased cell activation phenomena might play a role in the pathogenetic events leading to the development of angioimmunoblastic lymphadenopathy (AILD). In the present study we investigated the serum levels of some soluble molecules related to cell activation in 24 patients with AILD at presentation. In particular, we measured by immunoenzymatic or immunoradiometric techniques the levels of the Tac peptide (sIL-2R), soluble CD30 (sCD30) and CD8 (sCD8) antigens, and gamma-IFN (gIFN). The results show that all the above molecules are increased as compared to normal controls, with a different pattern of increase for the different molecules. The sIL-2R levels were very high in all cases with no overlap between AILD and control samples (mean 6315 +/- 3374 U/ml, controls 271 +/- 112 U/ml, P less than 0.001). Very high values of the sCD30 antigen (722 +/- 895 U/ml) were detected in all cases but five, as opposed to the lack of detectable levels in controls. A significant increase of sCD8 (978 +/- 646 U/ml, controls 334 +/- 95 U/ml, P less than 0.01) and gIFN (329 +/- 236 U/ml, controls 97 +/- 43 U/ml, P less than 0.01) was also observed with some overlap between AILD samples and controls. The a...Continue Reading

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Citations

Feb 6, 2003·International Journal of Hematology·Ryouichi HorieToshiki Watanabe
Dec 1, 2011·Pathology Oncology Research : POR·Edit PáyerArpád Illés
Oct 12, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·F DelfantiP Biswas
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Jun 5, 2003·British Journal of Haematology·Ahmet DoganChara Kyriakou
Jan 1, 1992·Medical Oncology and Tumor Pharmacotherapy·Y IizukaT Horie

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