PMID: 8968454Dec 1, 1996Paper

Increased serum lithium concentration secondary to treatment with tiaprofenic acid and fosinopril

The Annals of Pharmacotherapy
C P Alderman, K S Lindsay

Abstract

To describe a patient in whom the administration of tiaprofenic acid and fosinopril was associated with decreased lithium clearance, resulting in increased serum lithium concentrations. A woman treated with lithium for bipolar affective disorder was concurrently treated with tiaprofenic acid 200 mg tid for shoulder pain. Previously initiated treatment with fosinopril was maintained during this time. The urinary lithium clearance was decreased during this combination therapy, necessitating a reduction in the lithium dosage. Lithium is approximately 80% reabsorbed in the proximal tubule, and the addition of tiaprofenic acid may have resulted in enhanced tubular lithium reabsorption. The possible influence of concurrent fosinopril therapy may also have contributed to altered lithium pharmacokinetics in this case. Serum lithium concentrations should be monitored if patients taking lithium are treated with tiaprofenic acid.

Citations

May 20, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Ryan GatesCanh-Nhut Nguyen
Dec 3, 2015·Journal of Hypertension·Valeria BisogniGian Paolo Rossi
Oct 28, 2016·Environmental Science and Pollution Research International·Babar ShahzadGhazanfar Abbas
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·R T Timmer, J M Sands

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