PMID: 9175936May 1, 1997Paper

Increased serum NG-hydroxy-L-arginine in patients with rheumatoid arthritis and systemic lupus erythematosus as an index of an increased nitric oxide synthase activity

Annals of the Rheumatic Diseases
R WigandM Hecker

Abstract

To determine the feasibility of monitoring the serum concentration of NG-hydroxy-L-arginine (L-NHA) as an index of an increased nitric oxide (NO) synthase activity in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) compared with nitrate (NO3-), the major circulating metabolite of NO whose concentration is influenced by dietary intake. The serum concentrations of L-NHA, L-arginine (L-Arg), and NO3- were determined in 33 patients with RA, 25 patients with SLE and, 29 healthy subjects. Serum L-NHA was significantly increased in RA patients with high disease activity (287% of control, p < 0.01), but not with low disease activity (115%), as well as in patients with SLE (173%, p < 0.01). In contrast, serum NO3- did not differ significantly between either group of patients and the respective control group. NO synthase activity or expression, or both, is upregulated in RA patients with high disease activity and in patients with SLE. Serum L-NHA seems to be a more specific and reliable index of an increased activity of this enzyme in patients with acute or chronic inflammatory diseases than NO3-.

Citations

Nov 28, 2012·Clinical and Experimental Medicine·Rizwan Ahmad, Haseeb Ahsan
Mar 10, 2009·European Journal of Pharmacology·Hon-Pin WangBor-Show Tzang
Jul 24, 2012·Clinical Biochemistry·Tugrul PurnakIlyas Tenlik
Jan 19, 2000·Nitric Oxide : Biology and Chemistry·A WanchuP Bambery
Sep 9, 2006·Biochemical and Biophysical Research Communications·Bernd ClementSabine Heberling
Feb 15, 2001·The British Journal of Nutrition·W B Grant
Oct 14, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·A WanchuP Bambery
Dec 28, 2004·Chembiochem : a European Journal of Chemical Biology·Jon M FukutoKendall N Houk
Jun 25, 2005·Journal of Vascular Research·Petra BeranovaBernard Muller
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Ines HardyGil Hardy
Sep 14, 2007·Scandinavian Journal of Rheumatology·K VuolteenahoE Moilanen
Feb 18, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Vishal Bansal, Juan B Ochoa
Apr 12, 2001·The British Journal of Nutrition·L G Darlington, T W Stone
Mar 27, 2013·The Physician and Sportsmedicine·Jill N Barnes, Hirofumi Tanaka
Sep 12, 2017·Metabolomics : Official Journal of the Metabolomic Society·Izabella SurowiecJohan Trygg
Apr 27, 2002·American Journal of Surgery·Peter B SoetersNicolaas E P Deutz

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