Increased serum phosphodiesterase activity in women with pre-eclampsia

BJOG : an International Journal of Obstetrics and Gynaecology
B E Pinheiro da CostaJ A Guimarães

Abstract

To measure the activity of serum phosphodiesterase (PDE) in pre-eclampsia. Case-control study. Nephrology Laboratory and Obstetrics Unit at São Lucas Hospital from Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. Twenty-nine normal and 28 pregnant women with pre-eclampsia. Serum was collected from women with pre-eclampsia, at the time of diagnosis, and from gestation-matched controls. Circulating PDE activity was assessed by measuring consumption of the substrate thymidine 5'-monophosphate p-nitrophenyl ester and expressed as PDE units/l. Serum PDE Activity. Mean substrate consumption was higher in pre-eclamptic condition (V(max)= 15.8 +/- 1.4 versus 12.7 +/- 0.9 U/L, P= 3.7 x 10(-14)). These data suggest that altered PDE activity may play a role in pre-eclampsia endothelial dysfunction.

References

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Citations

Jul 30, 2010·Cell Biochemistry and Biophysics·Bartira Ercília Pinheiro da CostaCarlos Eduardo Poli-de-Figueiredo
Jan 19, 2012·Clinical and Experimental Hypertension : CHE·Edibe KarasuBora Dinc
Jul 1, 2011·Pregnancy Hypertension·Edibe KarasuBora Dinc
Feb 1, 2008·European Journal of Pharmacology·António José Santos-SilvaIgnacio Verde
Mar 24, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Breno José Acauan FilhoCarlos Eduardo Poli-de-Figueiredo
Oct 11, 2008·American Journal of Obstetrics and Gynecology·Suzanne L MillerEuan M Wallace
May 30, 2013·International Journal of Cardiology·Matias Costa VieiraBartira Ercília Pinheiro da Costa
Dec 30, 2014·Trends in Molecular Medicine·Styliani Goulopoulou, Sandra T Davidge
May 26, 2016·São Paulo Medical Journal = Revista Paulista De Medicina·Antonia Angulo-TuestaDaniel Alves Natalizi
Apr 7, 2020·American Journal of Physiology. Renal Physiology·Hannah R Turbeville, Jennifer M Sasser
Jul 28, 2018·Current Hypertension Reports·Anne Brandolt LarréCarlos Eduardo Poli-de-Figueiredo
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology

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