Increased serum remnant lipoproteins in patients with apolipoprotein E7 (apo E Suita)

Atherosclerosis
K YanagiY Matsuzawa

Abstract

Apolipoprotein (apo) E7 was originally identified by Yamamura et al. in subjects with atherosclerotic cardiovascular diseases (J. Clin. Invest. 1984;74:1229). However, the lipoprotein abnormalities associated with apo E7 phenotype have not been elucidated. In the current study, to clarify the physiological roles of apo E7, lipoprotein abnormalities were studied in 12 apo E7 heterozygotes. A total of seven subjects were hyperlipidemic and five subjects were normolipidemic. The apo E phenotype was apo E7/3 in 11 subjects and apo E7/4 in one subject. Polymerase chain reaction revealed that all of the subjects with apo E7 phenotype had the same mutation as that of apo E(Suita) as reported previously (J. Biochem. 1989;105:249). All the hyperlipidemic subjects were over 40 years of age and two of them also had and severe coronary heart disease. Ultracentrifugal analysis revealed that the cholesterol level both in very low density lipoprotein and in intermediate density lipoprotein (IDL) was substantially higher in hyperlipidemic apo E7 heterozygotes, compared with control subjects and that the IDL cholesterol was also increased even in normolipidemic apo E7 heterozygotes. Polyacrylamide gel electrophoresis of lipoproteins showed a mi...Continue Reading

Citations

Apr 14, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Kirsty GreenowDipak P Ramji
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M M HoffmannW März
Jun 14, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Makoto AraiMinoru Okubo
May 1, 2021·Frontiers in Cardiovascular Medicine·Hayato TadaMasa-Aki Kawashiri
Jun 1, 2021·Atherosclerosis·Yara Abou KhalilMathilde Varret
Oct 24, 1998·Endocrinology and Metabolism Clinics of North America·J Davignon, J Genest

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