Increased serum soluble CD8 or suppressor/cytotoxic antigen concentrations in depression: suppressive effects of glucocorticoids

Biological Psychiatry
M MaesR Desnyder

Abstract

There is now some evidence that depression and, in particular, major depression, is accompanied by signs of an immune response, and that there are reciprocal relationships between immune function and increased hypothalamic-pituitary-adrenal (HPA) axis activity in depression. To further examine the above phenomena, this study has assayed serum soluble CD8 (sCD8) concentrations in 22 normal controls, 27 minor depressed, 37 major depressed, and 26 melancholic depressed patients. Serum sCD8 was significantly higher in depressed patients versus normal controls. Thirty-five percent of the depressed subjects had increased sCD8 serum levels (i.e., > 560 U/mL) with a specificity of 95.4%. Dexamethasone administration (1 mg PO) had a significant suppressive effect on serum sCD8. In depressed subjects, there were significant and negative relationships between serum sCD8 and postdexamethasone cortisol values. The results suggest the presence of an ongoing lymphocyte activation in depression, which may be down-regulated by increased HPA axis activity in that illness.

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Citations

Apr 15, 2004·Journal of Neuroimmunology·Hsing-Cheng LiuSy-Jye Leu
May 10, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M CorcosPh Jeammet
Jun 24, 2004·The Australian and New Zealand Journal of Psychiatry·Peter Ellis, UNKNOWN Royal Australian and New Zealand College of Psychiatrists Clinical Practice Guidelines Team for Depression
Feb 24, 2016·Neuroscience and Biobehavioral Reviews·Anastasiya SlyepchenkoAndré F Carvalho
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael Maes
Feb 7, 2006·Journal of Neuroimmunology·Lenin PavónGerhard Heinze
Apr 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A ZagerS Tufik
Nov 10, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Antonio ChahineAdam W Carrico

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