Increased sheep lung vascular permeability caused by histamine.

Circulation Research
K L Brigham, P J Owen

Abstract

To see whether histamine increases lung vascular permeability to protein, we compared the effects of steady-state histamine infusions on lung vascular pressures, lung lymph flow, and lung lymph protein content with the effects of mechanically elevated lung vascular pressures on these variables in the same unanesthetized sheep. We surgically implanted catheters in the pulmonary artery, the left atrium, the superior vena cava, and a main lung lymphatic. After the sheep had recovered from surgery, we carried out steady-state experiments without anesthesia. Histamine induced a dose-related, quickly reversible increase in lung lymph flow without affecting pulmonary artery pressure, and it caused left atrial pressure to fall. During 4-hour intravenous 4-mug/kg min-1 histamine infusions, lymph flow and lymph protein clearance (lymph flow X lymph-plasma protein concentration ratio) increased more than they did with mechanically elevated pressure even though vascular pressures fell. Lymph-plasma protein ratios decreased linearly with increasing lymph flow during increased pressure experiments, but during histamine infusions the ratios did not decrease even though lymph flow increased 2-6-fold. Lymph clearance and permeability-surface ar...Continue Reading

References

Apr 6, 1968·Lancet·J F Riordan, G Walters
Oct 1, 1974·The Journal of Clinical Investigation·K L BrighamN C Staub
Feb 1, 1973·The New England Journal of Medicine·E D RobinR Zelis
Aug 1, 1973·The Journal of Clinical Investigation·K L Brigham, J D Snell
Jul 1, 1974·Physiological Reviews·N C Staub
Nov 1, 1972·The American Journal of Physiology·G J GregaF J Haddy
Nov 1, 1972·The American Journal of Physiology·F J HaddyG J Grega
Mar 1, 1969·The Journal of Clinical Investigation·C A GoreskyB E Wangel
Mar 1, 1971·Acta Physiologica Scandinavica·K A Eliassen
Dec 1, 1971·The Journal of Clinical Investigation·J B Glazier, J F Murray
Dec 26, 1969·Science·G G PietraA P Fishman
Dec 1, 1970·The American Journal of Physiology·D G Garlick, E M Renkin
Jan 1, 1956·Dermatologica·R KOOIJ
Aug 1, 1957·The American Journal of Physiology·H H SHIRLEYH S MAYERSON
Jun 1, 1963·Bacteriological Reviews·W G SPECTOR, D A WILLOUGHBY
Mar 1, 1964·Acta Physiologica Scandinavica·S JACOBSSON, I KJELLMER
Apr 1, 1964·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·H W FLOREY
Nov 1, 1964·Acta Physiologica Scandinavica·N H ARESKOGG GROTTE
May 1, 1965·Circulation Research·M L PEARCEJ BEAZELL
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNOG I SCHOEFL
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNO, G E PALADE
Jul 1, 1962·The American Journal of Physiology·H S MAYERSONP MAYERSON

❮ Previous
Next ❯

Citations

May 1, 1981·Agents and Actions·N F VoelkelJ T Reeves
Jan 1, 1987·Annals of Biomedical Engineering·R J RoselliT R Harris
Jan 1, 1985·Lung·A B MalikK E Burhop
Jun 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D E Withington, J V Aranda
Jan 1, 1991·Journal of Anesthesia·K OkamotoY Takumi
Sep 1, 1979·Microvascular Research·J E McNamee, N C Staub
Nov 1, 1978·Respiration Physiology·C G Irvin, J A Dempsey
May 1, 1980·Respiration Physiology·J H NewmanJ T Reeves
Jul 1, 1993·Respiration Physiology·L Y Lee, R F Morton
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers
Nov 1, 1977·The Journal of Clinical Investigation·R D Bland, D D McMillan
May 1, 1978·The Journal of Clinical Investigation·C R McKeenT R Harris
Jan 1, 1979·The Journal of Clinical Investigation·R E BowersJ A Oates
Nov 1, 1981·The Journal of Clinical Investigation·A C Heflin, K L Brigham
Dec 1, 1983·The Journal of Clinical Investigation·I M Dauber, J V Weil
Aug 3, 1999·The Journal of Clinical Investigation·E J CampbellC A Owen
May 15, 1987·Journal of Chromatography·P Herrero, R J Roselli
Mar 1, 1989·Experimental Lung Research·D E McClureW J Weidner
Feb 1, 1983·Experimental Lung Research·B T PetersonK L Brigham
Jan 1, 1985·Experimental Lung Research·A TaylorR J Korthuis
Jun 1, 1979·Chest·R W CarlsonM H Weil
Jul 1, 1982·Chest·T L Petty, A A Fowler
Oct 1, 1987·British Journal of Diseases of the Chest·M C DombertJ P Marmuse
Mar 1, 1981·The Journal of Surgical Research·J C StothertC J Carrico
Feb 1, 1991·The Journal of Surgical Research·K ByrneH J Sugerman
Sep 1, 1992·Pulmonary Pharmacology·T S HakimR P Michel
May 1, 1976·Microvascular Research·K L BrighamR E Bowers
Apr 1, 1982·The Journal of Surgical Research·R J Mullins, D R Bell
Jan 1, 1982·Annals of the New York Academy of Sciences·J M Hughes
Jan 1, 1982·Annals of the New York Academy of Sciences·W J SibbaldF S Schurch
Jan 1, 1982·Annals of the New York Academy of Sciences·J V Hurley
Jan 1, 1982·Annals of the New York Academy of Sciences·T R Harris, K L Brigham
Oct 1, 1988·British Journal of Pharmacology·S E WebberJ G Widdicombe
May 4, 2017·International Journal of Molecular Sciences·Sarit PalAnatoliy A Gashev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.