Increased sheep lung vascular permeability caused by Escherichia coli endotoxin

Circulation Research
K L BrighamJ Haynes

Abstract

We infused Escherichia coli endotoxin, 0.07-1.33 microgram/kg, intravenously into chronically instrumented unanesthetized sheep and measured pulmonary arterial and left atrial pressures, lung lymph flow, lymph and blood plasma protein concentrations, and arterial blood gases. Endotoxin caused a biphasic reaction: an early phase of pulmonary hypertension and a long late phase of steady state increased pulmonary vascular permeability during which pulmonary arterial and left atrial pressures were not increased significantly and lung lymph flow was 5 times the baseline value. Lymph: plasma total protein concentration ratio during the late phase (0.76 +/- 0.04) was significantly (P less than 0.05) higher than during baseline (0.66 +/- 0.03). The lymph response was reproducible. Lung lymph clearance of endogenous proteins with molecular radii (r) 35.5 to 96 A was increased during the steady state late phase of the reaction, but, as during baseline, clearance decreased as r increased. The endotoxin reaction was similar to the reaction to infusing whole Pseudomonas bacteria, except that endotoxin had less effect on pressures during the steady state response and caused a relatively larger increase in lymph clearance of large proteins. W...Continue Reading

References

May 1, 1976·Microvascular Research·K L BrighamR E Bowers
Jun 1, 1976·The American Journal of Physiology·C R VreimN C Staub
Sep 1, 1976·Microvascular Research·L H Blake, N C Staub
Sep 11, 1975·Circulation Research·A J ErdmannN C Staub
Nov 1, 1975·Circulation Research·K L Brigham, P J Owen
Nov 11, 1975·The Journal of Surgical Research·N C StaubW C Woolverton
Oct 1, 1974·The Journal of Clinical Investigation·K L BrighamN C Staub
Feb 1, 1973·The New England Journal of Medicine·E D RobinR Zelis
Jul 1, 1974·Physiological Reviews·N C Staub
Dec 1, 1972·Journal of Applied Physiology·J T ReevesM Estridge
Jul 11, 1969·The American Journal of Physiology·J D Snell, L H Ramsey
Jul 1, 1972·Archives of Internal Medicine·E D RobinR Gaudio
Apr 13, 1964·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·L BARR, W BERGER
Sep 1, 1964·The American Journal of Physiology·S CHIENM I GREGERSEN

❮ Previous
Next ❯

Citations

Jan 1, 1984·Intensive Care Medicine·W J Sibbald
Jan 1, 1990·European Journal of Nuclear Medicine·J T Christenson, A Owunwanne
Jan 1, 1992·Veterinary Research Communications·B UrbainM Ansay
Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·N HaraK Inokuchi
Aug 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E J MillerA B Cohen
Sep 9, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Paul FarandOlivier Lesur
Dec 17, 1991·European Journal of Pharmacology·A KleeD Seiffge
May 2, 1991·European Journal of Pharmacology·M C Dyson, P J Kadowitz
Mar 16, 1993·European Journal of Pharmacology·E WeitzbergJ M Lundberg
Sep 1, 1988·The Journal of Surgical Research·J O BasadreD L Traber
Aug 1, 1981·Physiology & Behavior·C A BaileC A Catanzaro
Mar 1, 1988·Respiration Physiology·K Fujimoto, T Kobayashi
Aug 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·C F AmaralN A de Rezende
Jan 1, 1988·Molecular Aspects of Medicine·N C OlsonC E McCall
Mar 10, 1997·Journal of Immunological Methods·R J SzarkaR H Smith
Oct 17, 1998·Burns : Journal of the International Society for Burn Injuries·H IshiharaA Matsuki
May 17, 2003·Journal of Pharmacological and Toxicological Methods·Helen JonesClive P Page
Jan 3, 2001·The British Journal of Surgery·S J Parker, P E Watkins
Mar 17, 2001·Clinical and Experimental Pharmacology & Physiology·R P LeeH I Chen
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C J HorvathA B Malik
Jan 1, 1989·Annals of Surgery·J M KlausnerH B Hechtman
Oct 1, 1993·Annals of Surgery·R SimpsonH B Hechtman
Jan 22, 2002·Critical Care Medicine·S KutzscheL J Bjertnaes
Dec 12, 2012·Critical Care Medicine·Kendra N IskanderDaniel G Remick

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.