Increased sibling mortality in children with fetal alcohol syndrome

Addiction Biology
Larry BurdJohn Martsolf

Abstract

We compared the rate of all-cause mortality in siblings of children diagnosed with fetal alcohol syndrome (FAS) with the siblings of matched controls. The siblings of children with FAS had increased mortality (11.4%) compared with matched controls (2.0%), a 530% increase in mortality. The age of death in case siblings deaths occurred later (between 1 day and 7 years) compared with the controls (1 day to 4 years) [odds ratio (OR)=2.4 (0.4-15.6)]. Siblings of children with FAS had increased risk of death due to infectious illness [OR=13.7 (1.2-361)] and sudden infant death syndrome compared with controls [OR=10.2 (1.2-75.1)]. A diagnosis of FAS is an important risk marker for mortality in the siblings of the proband even if they do not have FAS. Maternal alcoholism appears to be a useful risk marker for increased mortality risk in diagnosed cases and their siblings. This has important implications in the management of family members of children with FAS.

References

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Citations

Apr 19, 2011·Neuropsychology Review·Edward P RileyKenneth R Warren
Jun 21, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Carl E Hunt, Fern R Hauck
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Mathias ZinkRainer Spanagel
Apr 2, 2008·Congenital Heart Disease·Larry BurdMarilyn G Klug
Mar 28, 2006·The Journal of the Royal Society for the Promotion of Health·Larry BurdJacob Kerbeshian
Jun 30, 2004·Addiction Biology·Larry Burd
Jan 31, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Ryan Hofer, Larry Burd
Apr 26, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Larry Burd, Ryan Hofer
Jul 21, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Albert E ChudleyMichelle Edwards
Mar 14, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Larry BurdJacob Kerbeshian
Aug 4, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Larry BurdHein Odendaal
Nov 16, 2014·Advances in Nutrition·Jennifer K YoungMiyoung Suh
Oct 23, 2019·International Journal of Environmental Research and Public Health·Larry Burd, Svetlana Popova
May 28, 2013·Evidence-based Medicine·Larry Burd

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