PMID: 8592591Oct 1, 1995Paper

Increased silicon levels in dialysis patients due to high silicon content in the drinking water, inadequate water treatment procedures, and concentrate contamination: a multicentre study

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
P C D'HaeseL V Lamberts

Abstract

Although silicon is considered as an essential element, little is known about the basic effects and clinical significance of increased concentrations of the element in dialysis patients. In a multicentre study we found silicon levels in haemodialysis (HD) patients to be markedly increased. In these patients silicon concentrations were significantly higher than those noted in subjects with normal renal function as well as in patients with chronic renal failure not yet in dialysis and patients treated by continuous ambulatory peritoneal dialysis (CAPD). Moreover we noted that in both HD and CAPD patients mean silicon levels differed from one centre to another. Also, was there in the HD population a significant difference in serum silicon levels among patients from different countries. In HD patients differences in serum silicon levels were either due to the use of silicon contaminated dialysis fluids or an increased oral intake of the element mainly originating from the high silicon content of the drinking water. Silicon contamination of the dialysis fluid was found to be due to either the use of reverse osmosis membranes that insufficiently retain the element during water treatment or by the addition of concentrates containing h...Continue Reading

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