Increased sinusoidal resistance is responsible for the basal state and endothelin-induced venoconstriction in perfused cirrhotic rat liver

Pflügers Archiv : European journal of physiology
Toshishige ShibamotoShozo Koyama

Abstract

The localization of increased intrahepatic vascular resistance and the segmental vascular responsiveness to endothelin-1 are not well known in liver cirrhosis. We determined the segmental vascular resistances and their response to endothelin-1 of isolated portally perfused bile duct ligation (BDL)-induced cirrhotic rat livers. The portal occlusion pressure (Ppo) and the hepatic venous occlusion pressure (Phvo) were obtained by analyzing the profiles of the portal (Ppv) and hepatic venous (Phv) pressures during the double occlusion maneuver of simultaneous occlusions of the inflow and outflow perfusion lines. From the pressure gradients among Ppv, Ppo, Phvo, and Phv, the portal-hepatic venous resistance was assigned to three segments of the portal [Rpv = (Ppv - Ppo)/blood flow (Q)], sinusoidal [Rsinus = (Ppo - Phvo)/Q] and hepatic venous [Rhv = (Phvo - Phv)/Q] resistances. Rsinus, but not Rpv or Rhv, was significantly greater in BDL livers than in sham livers. Endothelin-1 (0.1-1 nM) increased Rpv and Rsinus to a similar magnitude, but not Rhv, in both sham and BDL. At 3 nM, the responsiveness of Rpv was smaller in BDL than in sham, but that of Rsinus were similar between in BDL and sham. In conclusion, increased sinusoidal resi...Continue Reading

References

Dec 17, 1992·The New England Journal of Medicine·K MooreK Badr
Nov 1, 1992·British Journal of Pharmacology·M J SumnerI S Watts
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S K SarinR J Groszmann
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G JacobA Bomzon
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D J Morgan, A J McLean
Feb 1, 1990·Seminars in Liver Disease·H TsukamotoS W French
May 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Pomier-LayrarguesP M Huet
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y Shibayama, K Nakata
Oct 1, 1981·Pflügers Archiv : European journal of physiology·D LebrecS Lacroix
Sep 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L M BlendisY Isreal
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G LaffiP Gentilini
Oct 1, 1994·Gastroenterology·M HartlebD Lebrec
Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BauerM G Clemens
Aug 1, 1995·The American Journal of Physiology·J X ZhangM G Clemens
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J RosJ Rodés
Apr 11, 1994·The American Journal of Physiology·J X ZhangM G Clemens
Apr 1, 1993·The Journal of Clinical Investigation·M OshitaH Fusamoto
May 1, 1993·Gastroenterology·M AsbertJ Rodés
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C Rockey, R A Weisiger
Dec 1, 1995·Journal of Pharmacological and Toxicological Methods·B AlexanderI S Benjamin
Sep 1, 1996·International Journal of Microcirculation, Clinical and Experimental·Y ItoA Kakita
Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D Rockey
Apr 1, 1997·Journal of Gastroenterology and Hepatology·A J ElliotH J Grossman
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ShahR J Groszmann
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C RockeyC Housset
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L D DeLeveG C Kanel
Oct 5, 2001·Seminars in Liver Disease·D C Rockey
Dec 20, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mauricio R Loureiro-SilvaRoberto J Groszmann
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexander ZipprichGerhard Kleber
Aug 30, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Chiaki KamikadoShozo Koyama
Oct 15, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Yoshiya ItoRobert S McCuskey
Jun 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Toshishige ShibamotoYasutaka Kurata

❮ Previous
Next ❯

Citations

Oct 22, 2009·Clinical and Experimental Pharmacology & Physiology·Patrícia de Souza RossignoliAgnaldo B Chies
Feb 2, 2012·World Journal of Gastroenterology : WJG·Wen-Ting BinXiao-Lin Shi
Oct 19, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Lorette NoiretRajiv Jalan
Jun 7, 2015·Archives of Toxicology·Sara Crespo YanguasMathieu Vinken
Jan 13, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Denise Van der GraaffSven M Francque

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Chiaki KamikadoShozo Koyama
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
P S KamathD K Rorie
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Zonghai RuanMatomo Nishio
© 2021 Meta ULC. All rights reserved