May 19, 1976

Increased sister chromatid exchange events in the human late replicating X

Human Genetics
W SchnedlH G Schwarzacher

Abstract

Human female blood cultures were labeled with BrdU for detecting sister chromatid exchanges (SCEs) by the Hoechst 33258 fluorescence technique. Late labeling with 3H-thymidine and autoradiography allowed the identification of the late replicating X. The mean number of SCEs in the cells was 13. The isopycnotic X showed an exchange frequency according to its relative length in the karyotype; in the late replicating X a doubled number of SCE events was observed.

Mentioned in this Paper

Thymidine
Sister Chromatid Exchange
Sex Chromosomes
Chromatids
Crossing Over, Genetic
Autoradiography
M Phase, Mitotic
Bromodeoxyuridine
Karyotype Determination Procedure
Hoechst 33258

About this Paper

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