Dec 1, 1980

Increased sister chromatid exchange frequencies in lymphocytes of nurses handling cytostatic drugs

Scandinavian Journal of Work, Environment & Health
H NorppaE Nordman


In oncology units, personnel handling chemotherapeutic drugs may occasionally be exposed to small amounts of genotoxic agents. This exposure was obviously the cause of the increased frequencies of sister chromatid exchange (SCE) observed in nurses in daily contact with cytostatics (N = 20, mean SCEs/cell +/- SE 9.4 +/- 0.3) as compared to a group of office workers (N = 10, mean SCEs/cell 8.1 +/- 0.3). The oncology nurses also had a higher SCE frequency than other hospital nurses (N = 10, mean SCEs/cell 8.7 +/- 0.2), but this difference was not statistically significant. The SCEs of patients under chemotherapy were about five times higher (mean SCEs/cell 36.8 +/- 0.6) than those of healthy subjects.

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Mentioned in this Paper

Antineoplastic Agents
Sister Chromatid Exchange
Lymphoid Cells
Occupational Diseases
Crossing Over, Genetic
Substance-Related Disorders

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