Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Madina NaimiEvangelia Tsiani

Abstract

Stimulation of the energy sensor AMP-activated kinase (AMPK) has been viewed as a targeted approach to increase glucose uptake by skeletal muscle and control blood glucose homeostasis. Rosemary extract (RE) has been reported to activate AMPK in hepatocytes and reduce blood glucose levels in vivo but its effects on skeletal muscle are not known. In the present study, we examined the effects of RE and the mechanism of regulation of glucose uptake in muscle cells. RE stimulated glucose uptake in L6 myotubes in a dose- and time-dependent manner. Maximum stimulation was seen with 5 μg/mL of RE for 4 h (184% ± 5.07% of control, p < 0.001), a response comparable to maximum insulin (207% ± 5.26%, p < 0.001) and metformin (216% ± 8.77%, p < 0.001) stimulation. RE did not affect insulin receptor substrate 1 and Akt phosphorylation but significantly increased AMPK and acetyl-CoA carboxylase phosphorylation. Furthermore, the RE-stimulated glucose uptake was significantly reduced by the AMPK inhibitor compound C, but remained unchanged by the PI3K inhibitor, wortmannin. RE did not affect GLUT4 or GLUT1 glucose transporter translocation in contrast with a significant translocation of both transporters seen with insulin or metformin treatment...Continue Reading

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Citations

May 15, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Faezeh Vahdati HassaniHossein Hosseinzadeh
Dec 17, 2016·Expert Review of Gastroenterology & Hepatology·Tongzhi WuChristopher K Rayner
Oct 8, 2016·Clinical and Experimental Pharmacology & Physiology·Madina NaimiEvangelia Tsiani
Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Filip VlavcheskiEvangelia Tsiani
May 31, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tyler BarnesMarina Mourtzakis
Aug 17, 2019·Critical Reviews in Clinical Laboratory Sciences·Saeideh MomtazSeyed Mohammad Nabavi
Mar 24, 2020·Journal of Leukocyte Biology·Michael YousefAdam J MacNeil
Aug 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Hira ShakoorCarine Platat
May 2, 2018·International Journal of Molecular Sciences·Filip VlavcheskiEvangelia Tsiani
Nov 8, 2018·Nutrients·Filip Vlavcheski, Evangelia Tsiani
Oct 6, 2020·The American Journal of Chinese Medicine·Tian-Qi BaoPing Li
Jan 21, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Hesham ShamshoumEvangelia Tsiani

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