Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery

International Journal of Nanomedicine
Hongwei LinZhufen Lu

Abstract

The aim of this work was to develop a novel vesicular carrier, ultradeformable liposomes (UDLs), to expand the applications of the Chinese herbal medicine, imperatorin (IMP), and increase its transdermal delivery. In this study, we prepared IMP-loaded UDLs using the thin-film hydration method and evaluated their encapsulation efficiency, vesicle deformability, skin permeation, and the amounts accumulated in different depths of the skin in vitro. The influence of different charged surfactants on the properties of the UDLs was also investigated. The results showed that the UDLs containing cationic surfactants had high entrapment efficiency (60.32%±2.82%), an acceptable particle size (82.4±0.65 nm), high elasticity, and prolonged drug release. The penetration rate of IMP in cationic-UDLs was 3.45-fold greater than that of IMP suspension, which was the highest value among the vesicular carriers. UDLs modified with cationic surfactant also showed higher fluorescence intensity in deeper regions of the epidermis. The results of our study suggest that cationic surfactant-modified UDLs could increase the transdermal flux, prolong the release of the drug, and serve as an effective dermal delivery system for IMP.

Citations

Sep 26, 2020·International Journal of Molecular Sciences·Ruslan KashapovOleg Sinyashin
Dec 3, 2020·International Journal of Nanomedicine·Zhang Julia ZhangBozena Michniak-Kohn
Feb 8, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Junaid DarGul Majid Khan
Apr 11, 2020·International Journal of Pharmaceutics·Marianne J NaguibShaimaa M Badr-Eldin
Feb 25, 2021·International Journal of Nanomedicine·Malik Muhammad IrfanSaima Mahmood
Sep 15, 2021·Therapeutic Delivery·Andang MiatmokoWidji Soeratri
Oct 19, 2020·Current Pharmaceutical Design·Drashti Patel, Bappaditya Chatterjee

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Methods Mentioned

BETA
dynamic light scattering
fluorescence microscopy
infrared spectroscopy

Software Mentioned

SPSS
Image
Pro Plus

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