Increased sodium appetite stimulates c-fos expression in the organum vasculosum of the lamina terminalis

Neuroscience
J M LaneJ T Fitzsimons

Abstract

The relation between c-fos expression in the forebrain of Lister hooded rats and water and NaCl intakes was examined in response to systemic injection of angiotensin II, desoxycorticosterone, angiotensin II and desoxycorticosterone together, frusemide or low sodium diet, all treatments that induce a sodium appetite. Angiotensin II (1 mg/kg subcutaneously) caused significant increases in the 1-h intakes of water and 1.8% NaCl compared to controls, the effect on water intake being the greater. There was a similar increase in NaCl intake after four days' treatment with desoxycorticosterone (20 mg pellet subcutaneously) but water intake was not increased. The NaCl intake of rats given angiotensin II following desoxycorticosterone treatment was approximately the sum of the intakes after angiotensin II or desoxycorticosterone alone, but the water intake was slightly less than after angiotensin II alone. Frusemide pretreatment (4 mg/kg subcutaneously) caused an NaCl intake similar to that following angiotensin II and desoxycorticosterone but water intake was little affected. Low dietary sodium also increased salt appetite, as expected. These treatments were repeated in rats that were not allowed to drink NaCl, after which the brains w...Continue Reading

References

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Citations

Jul 23, 1999·Annals of the New York Academy of Sciences·A K JohnsonL Vivas
Nov 6, 2007·Experimental Physiology·Joel C Geerling, Arthur D Loewy
Jan 6, 2005·Neuroscience Letters·Haerishton Rubim Cavalcante-LimaLuís Carlos Reis
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Geneviève CharronDidier Mouginot
Jun 25, 1998·The American Journal of Physiology·R L ThunhorstA K Johnson
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Francis W FlynnMargaret E Clinton
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lucia F FranchiniLaura Vivas
Jul 23, 1998·Physiological Reviews·J T Fitzsimons
Dec 20, 2019·Pharmacological Reviews·Hermann Koepsell
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Z XuM G Ross
Dec 31, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cinthia V PastuskovasRobert L Thunhorst
Apr 13, 1999·The American Journal of Physiology·L F Franchini, L Vivas

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