Increased soluble IL-2 receptor levels during interferon and ribavirin treatment are associated with a good response in genotype 2a/2b patients with chronic hepatitis C

European Journal of Gastroenterology & Hepatology
Shintaro AbeMakoto Otsuki

Abstract

Serum levels of soluble interleukin-2 receptor (sIL-2R) are known to serve as a marker for the activation of T lymphocytes. We measured serum levels of sIL-2R in patients with chronic hepatitis C (CHC) during interferon (IFN)-based treatment to determine the correlation between those levels and therapeutic efficacy, and to clarify whether there is a difference in the activation of T lymphocytes among HCV genotypes after the treatment. Forty-four patients received IFN-alpha2b monotherapy (group IFN-M), whereas 82 patients received the combination therapy with IFN-alpha2b and ribavirin (group IFN+R). We measured serum sIL-2R levels in these patients before (T0) and 2 weeks (T2) after the treatment. The sustained virologic response rates in genotype 2a/2b patients were significantly higher than those in genotype 1b patients in both groups (P<0.005). In sustained virologic responders, sIL-2R levels at T2 were significantly higher than those at T0 in both groups (P<0.001). In nonresponders, sIL-2R levels at T2 were not different from those at T0 in group IFN-M, but were significantly higher than those at T0 in group IFN+R (P=0.0072). In genotype 1b patients, sIL-2R levels at T2 were not different from those at T0 in group IFN-M, but...Continue Reading

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Citations

Jan 28, 2010·Journal of Clinical Biochemistry and Nutrition·Naruaki KohgeYoshikazu Kinoshita
Apr 8, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Monica BassoAntonino Picciotto
Dec 11, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Koksal DeveciOmer Cevit
Jul 18, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian L Pearlman
Dec 12, 2020·Journal of the Chinese Medical Association : JCMA·Wei-Yu KaoWeu Wang

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