Increased soluble intercellular adhesion molecule-1, breast cancer and the acute phase response

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
A D BlannA D Baildam

Abstract

Abnormal levels of soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP) and von Willebrand factor (vWf) are commonly found in breast and other cancers. However, the relationship between these molecules is unclear as raised sICAM-1 and vWf may simply reflect an acute phase response. We tested the hypothesis that raised sICAM-1 and vWf are related to the acute phase response by measuring both markers by enzyme-linked immunosorbent assay, and CRP by dry chemistry, in 40 women with breast cancer (cases) and 40 age-matched controls. All three markers were raised in the cases compared with the controls [sICAM-1 (mean +/- SD), 281 +/- 70 versus 230 +/- 40 ng/ml; vWf (mean +/- SD), 139 +/- 33 versus 106 +/- 16 IU/dl; CRP (median), 7 (interquartile range, 5-11) versus 5 (4-6) mg/dl; all P < 0.01]. However, sICAM-1 correlated strongly with CRP (r = 0.67, P < 0.001) in the cases but there was no significant relationship between vWf and CRP (r = -0.15, P = 0.351). There were no significant correlations in the controls. We conclude that raised sICAM-1 in breast cancer, like the acute phase response, reflects inflammation, and that raised vWf seems likely to be independent of the acute phase response.

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Citations

Apr 11, 2008·Breast Cancer Research and Treatment·Brandon L PierceCornelia M Ulrich
Nov 14, 2013·Archives of Pharmacal Research·Mina Ham, Aree Moon
Aug 19, 2007·Journal of Epidemiology and Community Health·Katriina HeikkiläDebbie A Lawlor
Nov 26, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Julien Yockell-LelièvreMarie Audette
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Aug 21, 2007·Brain, Behavior, and Immunity·Paul J MillsRoland von Känel
Sep 12, 2016·Journal of Gastrointestinal Cancer·Ahmed Abdel-RazikWaleed Eldars
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Oct 17, 2020·BMC Pulmonary Medicine·Nozomu MotonoHidetaka Uramoto

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