Increased STAT1 Expression in High Grade Serous Ovarian Cancer Is Associated With a Better Outcome

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Juliana A JosahkianJeremy A Squire

Abstract

Recently it has been demonstrated that constitutively activated signal transducer and activator of transcription 1 (STAT1) gene expression may act as a biomarker of ovarian cancer chemotherapy response. In this study, our objective was to validate the use of STAT1 immunohistochemistry as a prognostic biomarker for disease outcome using a cohort derived from Latin America. We evaluated a cohort of Brazilian high-grade serous ovarian cancer, comprising 65 patients with outcome data covering more than 5 years to determine the prognostic and predictive value of STAT1 expression levels. High-grade serous ovarian cancer tumors were used to construct a tissue microarray. Exploratory analyses were conducted on clinical, histopathological, and STAT1 expression data that included descriptive statistics and Pearson correlative analyses. Survival curves for disease-free survival and overall survival were obtained by the Kaplan-Meier method, and the significance of homogeneity between the classes was assessed by log-rank statistics (Mantel-Cox). High expression of STAT1 in tumors was significantly associated with improved disease-free survival (P = 0.0256) and overall survival (P = 0.0193). Proportional hazards regression analysis showed ST...Continue Reading

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Citations

May 20, 2020·Therapeutic Advances in Medical Oncology·Jinguo ZhangGuoxiong Xu
Oct 13, 2020·Cancer Biology & Therapy·Fangran LiuGuoxiong Xu
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Manying ZhangYanhong Zhou
Apr 10, 2021·Frontiers in Cell and Developmental Biology·Xin LiGuoxiong Xu

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