Increased stress-induced intra-hippocampus corticosterone rise associated with memory impairments in middle-aged mice

Neurobiology of Learning and Memory
C TroncheD Béracochéa

Abstract

The present study investigates the relationships between hippocampal corticosterone concentrations and memory retrieval performance in stress and non-stress conditions, in both young (6 month-old) and middle-aged (16 month-old) mice. For this purpose, the time-course evolution of stress-induced corticosterone rise in the dorsal hippocampus (dHPC) was investigated in both young and middle-aged mice. In parallel, the evolution of memory retrieval patterns was assessed using a contextual serial discrimination task (CSD). Finally, metyrapone (corticosterone synthesis inhibitor) was administered in order to evaluate the stress-induced impact of corticosterone rise on contextual memory retrieval in middle-aged animals. Results showed that: (i) non-stressed middle-aged mice exhibited a memory retrieval pattern opposite to that of non-stressed young animals, but similar to that of stressed young mice; (ii) the impact of stress on memory performance was transient (90 min) in young, as compared to middle-aged mice (120 min); (iii) dHPC basal (non-stress) corticosterone level was significantly increased by ageing; (iv) acute stress induced a rapid (15 min) and transient (90 min) dHPC corticosterone rise in young mice, while exhibiting gre...Continue Reading

Citations

Jan 29, 2011·Psychopharmacology·Matthias VandesquilleDaniel Béracochéa
Oct 25, 2011·Development and Psychopathology·Theodore P BeauchaineNatalia Potapova
Aug 5, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rodolphe DoreyDaniel Béracochéa
Sep 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R DoreyD Béracochéa
Aug 12, 2014·Neurobiology of Aging·Joyce L W YauJonathan R Seckl
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Jul 5, 2015·General and Comparative Endocrinology·Michelle A Rensel, Barney A Schlinger
Oct 5, 2010·Pharmacology, Biochemistry, and Behavior·Christophe PierardDaniel Beracochea
May 27, 2014·Frontiers in Behavioral Neuroscience·Gaelle DominguezDaniel Béracochéa
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