Increased subjective symptom prevalence among workers exposed to trichloroethylene at sub-OEL levels

The Tohoku Journal of Experimental Medicine
Y T LiuO Inoue

Abstract

Over 100 workers exposed to trichloroethylene (TRI) mostly at less than 50 ppm during the production or vapor degreasing operation and about an equal number of the non-exposed control workers were examined for subjective symptoms, hematology, serum biochemistry, and sugar, protein and occult blood in urine. Essentially all the clinico-laboratory tests stayed normal, and there was no significant differences in the findings between the exposed and the controls. Thus, no clinically significant effects of TRI exposure were found in the blood and liver functions among the exposed workers as compared with the controls. The prevalence of the subjective symptoms was, however, significantly higher in the exposed group than in the controls, and dose-response relationship could be established in some selected symptoms such as nausea, heavy feeling in the head, forgetfulness, tremor in extremities, cramp in extremities and dry mouth, although the exposure was low. The findings warrant further attention to the effects of TRI especially on the central nervous system at the concentration lower than e.g., 50 ppm.

Citations

Jan 1, 1993·International Archives of Occupational and Environmental Health·K MizunumaM Ikeda
Apr 1, 1990·Bulletin of Environmental Contamination and Toxicology·T KawaiM Ikeda
Mar 15, 2006·International Archives of Occupational and Environmental Health·Hajime SamotoMasayuki Ikeda
Jun 18, 2011·International Journal of Hygiene and Environmental Health·Toshihiro KawamotoIwao Uchiyama
Aug 11, 2010·American Journal of Industrial Medicine·Katsuyuki MurataToyoto Iwata

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