Increased surface expression of CD11b receptors on polymorphonuclear leukocytes is not sufficient to sustain phagocytosis during Escherichia coli mastitis in early postpartum dairy cows

Veterinary Immunology and Immunopathology
H DosogneB Goddeeris

Abstract

Phagocytosis, CD11a and CD11b adhesion receptor expression, O2-production and maturity of circulating polymorphonuclear leukocytes (PMN) were studied during acute coliform mastitis in early postpartum dairy cows to obtain a better insight in the role of neutrophils in the pathology of this disease. The mammary gland of twelve newly calved high-yielding dairy cows was experimentally infected with Escherichia coli. Variability in clinical signs of mastitis and inhibition of milk production among cows was very high. There was a significant negative correlation between the number of circulating neutrophils immediately before infection and severity of mastitis represented by the decrease in milk production of non-infected quarters two days after infection. Pre-infection phagocytosis of E. coli, CD11a and CD11b receptor expression, phorbol myristate acetate (PMA)-induced O2-production and maturity of neutrophils on a per cell basis were not related to severity of mastitis. However, significant correlations between severity of mastitis and the total number of phagocytic PMN and mature PMN in blood immediately before infection were found. PMN characteristics responded differently to mastitis depending on the severity of the disease. Ne...Continue Reading

References

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Citations

Apr 12, 2002·Veterinary Immunology and Immunopathology·Araceli Diez-FraileChristian Burvenich
Jul 20, 2002·Veterinary Immunology and Immunopathology·J C Detilleux
Mar 20, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·D RysánekM Toman
Jun 1, 2002·Veterinary Clinical Pathology·Douglas J Weiss
Nov 1, 2012·BMC Veterinary Research·Matthew ShergerTracey L Papenfuss
Sep 1, 2004·American Journal of Veterinary Research·Araceli Diez-FrailleChristian Burvenich
Nov 30, 2002·Veterinary Microbiology·J E KornalijnslijperE N Noordhuizen-Stassen
Oct 9, 2004·The Veterinary Clinics of North America. Food Animal Practice·Andrew J Bradley, Martin J Green
May 8, 2014·Nutrition·Jean-François MalletChantal Matar
Jul 21, 2004·Journal of Dairy Science·F VangroenwegheC Burvenich
Mar 16, 2007·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·N J LitterioJ C Boggio
Apr 22, 2003·Journal of Dairy Science·H DosogneC Burvenich
Aug 9, 2003·Journal of Dairy Science·T LehtolainenS Pyörälä
Jun 23, 2007·Veterinary Research·Jalil MehrzadChristian Burvenich
Dec 19, 2002·Journal of Dairy Science·V Van MerrisC Burvenich
Jan 1, 2014·Journal of Veterinary Medicine·Mohamed Ezzat AlnakipJorge Barros-Velázquez
Apr 10, 2003·The Veterinary Clinics of North America. Food Animal Practice·Jeanne L Burton, Ronald J Erskine

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