Increased Susceptibility for Atrial and Ventricular Cardiac Arrhythmias in Mice Treated With a Single High Dose of Ibrutinib

The Canadian Journal of Cardiology
Jari M TuomiDouglas L Jones

Abstract

Atrial fibrillation is a side effect of ibrutinib, an irreversible inhibitor of Bruton tyrosine kinase used for treatment of B-cell lymphoproliferative disorders. We determined if single (2 or 10 mg/kg), or chronic (14 days) oral ibrutinib followed by 24-hour washout conferred susceptibility to electrically induced arrhythmias in 1-month-old male C57BL/6 mice. A single higher dose of ibrutinib increased arrhythmia inducibility. There was no inducibility difference after chronic dosing with washout. This suggests that high serum drug levels might be responsible for the proarrhythmic effect of ibrutinib and that an altered dosing strategy might mitigate the side effects.

Citations

Nov 27, 2019·Cancers·Bartosz PułaKrzysztof Jamroziak
Jul 24, 2018·Leukemia & Lymphoma·Constantine S Tam, Jennifer R Brown
Nov 2, 2019·Journal of Cardiovascular Translational Research·Mohammed Alomar, Michael G Fradley
Apr 10, 2019·American Journal of Hematology·Preetesh Jain, Michael Wang
Apr 2, 2020·Nature Reviews. Cardiology·Joerg Herrmann
Aug 16, 2019·Wiener klinische Wochenschrift·Markus C StühlingerMichael Steurer
Mar 30, 2021·Frontiers in Cell and Developmental Biology·H Yesid EstupiñánC I Edvard Smith
Aug 4, 2021·Current Oncology Reports·Maude SestierDarryl Leong
Aug 17, 2021·JACC. CardioOncology·Beibei DuKumaraswamy Nanthakumar
Sep 10, 2021·British Journal of Haematology·Chloe Pek Sang TangUNKNOWN BSH guidelines committee, UK CLL Forum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.