Increased susceptibility of rat gastric mucosa to ulcerogenic stimulation with aging. Role of capsaicin-sensitive sensory neurons

Digestive Diseases and Sciences
H MiyakeK Takeuchi

Abstract

We examined the influences of aging on gastric damage and gastric mucosal blood flow (GMBF) responses induced by acid back-diffusion, following the barrier disruption, and investigated the relation of capsaicin-sensitive sensory nerves to these changes. Male Fischer rats 3, 13, and 24 months old were used. Under urethane anesthesia, a rat stomach was mounted on a chamber, and gastric potential difference (PD), luminal H+ loss, and GMBF were measured before, during, and after exposure to 20 mM sodium taurocholate (TC) for 30 min, in the presence of 50 mM HCl. Mucosal exposure to TC caused surface cell damage, PD reduction, and acid back-diffusion (luminal H+ loss) in all groups of rats; delta PD reduction and the amount of H+ loss were not significantly different between young and aged rats. In young rats, a marked increase of GMBF was observed with luminal acid loss following TC treatment, yet it resulted in less damage in the gastric mucosa. In aged rats, however, such GMBF responses were apparently mitigated, leading to a significant worsening of gastric mucosal lesions induced by TC. Mucosal application of capsaicin (0.1 mg/ml) caused an increase of GMBF in young rats, but this response was significantly attenuated in aged r...Continue Reading

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Citations

Mar 4, 1999·European Journal of Pharmacology·T IchikawaK Hotta
Dec 1, 2007·Clinical Interventions in Aging·Julia L Newton
May 2, 2014·World Journal of Gastroenterology : WJG·Andrzej S TarnawskiMichael K Jones
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Feb 28, 2002·Best Practice & Research. Clinical Gastroenterology·J I Jones, C J Hawkey
Dec 21, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Amrita AhluwaliaAndrzej S Tarnawski
Aug 21, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jung Mook KangIn Sung Song
Jun 22, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Amrita AhluwaliaAndrzej S Tarnawski
Feb 15, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hyun Jin JoHyun Chae Jung
Dec 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adrian Eugen RoscaAna-Maria Zagrean

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