Increased susceptibility of spontaneously hypertensive rats to ventricular tachyarrhythmias in early hypertension

The Journal of Physiology
Thao P NguyenHrayr S Karagueuzian

Abstract

Hypertension is a risk factor for sudden cardiac death caused by ventricular tachycardia and fibrillation (VT/VF). We hypothesized that, in early hypertension, the susceptibility to stress-induced VT/VF increases. We compared the susceptibility of 5- to 6-month-old male spontaneously hypertensive rats (SHR) and age/sex-matched normotensive rats (NR) to VT/VF during challenge with oxidative stress (H2 O2 ; 0.15 mmol l(-1) ). We found that only SHR hearts exhibited left ventricular fibrosis and hypertrophy. H2 O2 promoted VT in all 30 SHR but none of the NR hearts. In 33% of SHR cases, focal VT degenerated to VF within 3 s. Simultaneous voltage-calcium optical mapping of Langendorff-perfused SHR hearts revealed that H2 O2 -induced VT/VF arose spontaneously from focal activations at the base and mid left ventricular epicardium. Microelectrode recording of SHR hearts showed that VT was initiated by early afterdepolarization (EAD)-mediated triggered activity. However, despite the increased susceptibility of SHR hearts to VT/VF, patch clamped isolated SHR ventricular myocytes developed EADs and triggered activity to the same extent as NR ventricular myocytes, except with larger EAD amplitude. During the early stages of hypertension, ...Continue Reading

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Citations

Sep 7, 2016·Current Hypertension Reports·Alissa A FrameRichard D Wainford
Nov 27, 2018·PLoS Computational Biology·Xiaodong HuangZhilin Qu
Apr 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Taro TenmaHisashi Yokoshiki
Feb 16, 2019·Frontiers in Physiology·Elizabeth M AnnoniElena G Tolkacheva

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