Increased susceptibility to infections before the diagnosis of immune thrombocytopenia

Journal of Thrombosis and Haemostasis : JTH
C EkstrandS Bahmanyar

Abstract

Infections after diagnosis of primary chronic immune thrombocytopenia (cITP) have mostly been connected to the immunomodulation treatment. Infections may trigger autoimmune diseases and may be a complication of an already impaired immune system. To investigate the association of cITP with infection before diagnosis. We also estimated the incidence of cITP based on the new definition by the International ITP Working Group. We identified 1087 adults with primary cITP between 2006 and 2012 using the Swedish Patient Register. Data on infections not already associated with secondary ITP were also retrieved from the register. The standardized incidence ratios (SIRs), using the rates from the general population, and 95% confidence intervals (CIs) were estimated as a measure of relative risk. We used data from the Prescribed Drug Register to estimate SIR for anti-infective treatment. The incidence of cITP was 2.30 per 100 000 person-years (95% CI, 2.15-2.45). cITP was associated with an increased risk of serious infections requiring inpatient or outpatient care within 5 years before cITP diagnosis (SIR = 8.74; 95% CI, 7.47-10.18). Higher magnitude SIRs were observed for candidiasis, viral infection at an unspecified site and acute uppe...Continue Reading

References

Jun 3, 1999·Transfusion Science·M L Rand, J F Wright
Apr 7, 2004·Mayo Clinic Proceedings·Roberto Stasi, Drew Provan
Apr 22, 2005·Critical Reviews in Oncology/hematology·Bin ZhouZhong Chao Han
Jun 9, 2005·Blood·Douglas B Cines, James B Bussel
Apr 28, 2009·Blood·Douglas B CinesEline T Luning Prak
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Marie JohannessonShahram Bahmanyar
Aug 1, 2009·Trends in Immunology·Shaye KivityYehuda Shoenfeld
Dec 18, 2009·Journal of Leukocyte Biology·Paolo SfrisoAndrea Doria
Feb 5, 2010·American Journal of Hematology·Deirdra R TerrellJames N George
Feb 18, 2011·Blood·Cindy NeunertUNKNOWN American Society of Hematology
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Jun 22, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sigurdur Y KristinssonLynn R Goldin
Aug 24, 2011·Acta Haematologica·Mahmoud H Ayesh Haj Yousef, Khaldoon M Alawneh
Nov 29, 2011·Current Medical Research and Opinion·Patrick F FogartyKelly M Grotzinger
Apr 6, 2012·Expert Review of Hematology·Henrik FrederiksenMette Nørgaard
Jul 20, 2012·Rheumatology International·Asli Gamze Sener, Ilhan Afsar
Aug 7, 2012·Journal of Thrombosis and Haemostasis : JTH·S Lakshmanan, A Cuker
May 25, 2013·Pharmacoepidemiology and Drug Safety·B WettermarkHt Sørensen
Dec 20, 2013·Current Allergy and Asthma Reports·Robert Root-Bernstein, DeLisa Fairweather
Jan 22, 2014·Autoimmunity Reviews·Ernest Lo, Sean Deane

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Citations

Jan 31, 2017·La Revue de médecine interne·G MoulisL Sailler
Jan 15, 2020·Infection and Immunity·Christina M SchultzRandall G Worth
Aug 23, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Charlotta EkstrandShahram Bahmanyar
Aug 28, 2020·Frontiers in Immunology·Conglei LiHeyu Ni
Sep 7, 2021·Expert Review of Hematology·Melanie SandvadNikolaj Mannering

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