PMID: 16508212Mar 2, 2006Paper

Increased susceptibility to Staphylococcus aureus colonization of the skin of the NOA mouse: a potentially useful animal model for evaluating antiseptic effects

Experimental Animals
Taizo KondoYasuhisa Shiomoto

Abstract

Isolation of bacteria from wet skin lesions was attempted using Naruto Research Institute Otsuka Atrichia (NOA) mice, which develop such lesions spontaneously at a high rate. As a result, Staphylococcus aureus was demonstrated to have colonized the wet skin lesions at high density. In addition, the isolated S. aureus was found to be similar to the strain of S. aureus thought to colonize the eczematous lesions seen in humans with atopic dermatitis. Furthermore, a survey of the S. aureus colonization status of NOA mice with no wet skin lesions confirmed colonization at higher density than in HR-1 mice as control, indicating that the skin of the NOA mouse has the novel characteristic of increased susceptibility to S. aureus colonization. Thus, by using changes in S. aureus counts as an index, the NOA mouse can be expected to serve as a useful animal model for evaluating the effects of topical antiseptics. The antiseptic effects of an ointment and a lotion containing chlorhexidine gluconate were confirmed using this animal model.

References

Feb 1, 1988·Clinical Cardiology·T SaikawaM Ito
May 1, 1974·The British Journal of Dermatology·J J LeydenA M Kligman
Feb 1, 1984·The Journal of Allergy and Clinical Immunology·J M Hanifin
Jun 1, 1993·The British Journal of Dermatology·J P McFaddenR D Camp
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·H KanzakiS Kanzaki
May 18, 2005·Experimental Animals·Taizo KondoAkira Momii

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Citations

Jan 8, 2013·Journal of Bacteriology·Yuki KatayamaKeiichi Hiramatsu

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