Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer

Medical Oncology
K L LiuJ H Fan

Abstract

Sushi repeat-containing protein X-linked 2 (SRPX2) is a novel chondroitin sulfate proteoglycan overexpressed in gastrointestinal cancer. Its role in tumor biology remains unknown. The aim of this study was to investigate the expression of SRPX2 in colorectal cancer and its potential association with cancer progression. The expression of SRPX2 and its clinicopathological significance was evaluated using immunohistochemistry in a tissue microarray including 88 colon cancer and pairing normal tissues. The impact of SRPX2 on behavior of colorectal cancer cells and possible mechanism was explored using gene transfection and silencing. Strong staining of SRPX2 was noted in 71 (80.7 %) of 88 colon cancer specimen and 30 (34.1 %) of 88 adjacent normal tissues (P < 0.001). The expression of SRPX2 was significantly correlated with histological differentiation grade (P = 0.003), infiltration depth (P = 0.003), and clinical stage (P = 0.006). The expression of SRPX2 was significantly higher in HCT116 than in HT29 and SW480 cells. Suppression of endogenous SRPX2 expression by small interfering ribonucleic acid (siRNA) in HCT116 cells resulted in significant reduction in the ability of cell proliferation, adhesion, migration, and invasion. U...Continue Reading

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Citations

Apr 18, 2018·The Journal of Comparative Neurology·Mehwish AnwerAsla Pitkänen
Dec 9, 2015·Cellular and Molecular Neurobiology·Haitao TangPeng Liang
Feb 18, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kuiliang LiuJing Wu
Jun 30, 2019·Nucleic Acids Research·Gabriel CasellaMyriam Gorospe
Jul 17, 2021·BMC Bioinformatics·Verônica R de Melo CostaRosario M Piro

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